23565-78-8

Upstream product

• 16846-10-9 methyl 2,6-dihydroxy-4-methylbenzoate 
• 100-39-0 benzyl bromide 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 23565-79-9 2,6-bis-benzyloxy-4-methyl-benzoic acid 
• 519-57-3 sulochrin 
• 178749-81-0 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzaldehyde 
• 178749-82-1 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzoic acid methyl ester 
• 247086-81-3 (4-benzyloxy-2-hydroxymethyl-6-methoxy-phenyl)-(2,6-bis-benzyloxy-4-methyl-phenyl)-methanone 
• 247086-79-9 5-benzyloxy-2-(2,6-bis-benzyloxy-4-methyl-benzoyl)-3-methoxy-benzoic acid 
• 178749-80-9 2,6-bis-benzyloxy-4-methyl-benzoic acid 5-benzyloxy-2-bromo-3-methoxy-benzyl ester 

Relevant academic research and scientific papers

Modular Dual-Tasked C-H Methylation via the Catellani Strategy

We report a dual-tasked methylation that is based on cooperative palladium/norbornene catalysis. Readily available (hetero)aryl halides (39 iodides and 4 bromides) and inexpensive MeOTs or trimethylphosphate are utilized as the substrates and methylating reagent, respectively. Six types of "ipso" terminations can modularly couple with this "ortho" C-H methylation to constitute a versatile methylation toolbox for preparing diversified methylated arenes. This toolbox features inexpensive methyl sources, excellent functional-group tolerance, simple reaction procedures, and scalability. Importantly, it can be uneventfully extended to isotope-labeled methylation by switching to the corresponding reagents CD3OTs or 13CH3OTs. Moreover, this toolbox can be applied to late-stage modification of biorelevant substrates with complete stereoretention. We believe these salient and practical features of our dual-tasked methylation toolbox will be welcomed by academic and industrial researchers.

Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation

Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester