235765-54-5Relevant academic research and scientific papers
Diastereo- and enantioselective synthesis of 4- and 3,4-substituted 2- acetoxy-butyrolactones
Enders, Dieter,Sun, Hongbin,Leusink, Frederik R.
, p. 6129 - 6138 (2007/10/03)
An efficient asymmetric synthesis of 4-mono-and 3,4-disubstituted 2- acetoxy-butyrolactones 2 has been developed, based on a hydrazone-mediated asymmetric aldol reaction, an intramolecular lactonization and a stereoselective hydrogenation of the resulting butenolides 1. An application of this process in the synthesis of the natural hunger substance 3 (ee = 90%) is also presented.
