118535-62-9

Usage

Chemical Properties

CLEAR COLORLESS LIQUID

Upstream product

• 118535-71-0 (S)-2-(1-Ethyl-1-methoxy-propyl)-1-nitroso-pyrrolidine 
• 118970-93-7 (S)-(-)-1-benzyl-2-(1-hydroxy-1-ethylpropyl)-pyrrolidine 
• 118970-97-1 (S)-(-)-1-benzyl-2-(1-methoxy-1-ethylpropyl)-pyrrolidine 
• 147-85-3 L-proline 
• 5817-26-5 ethyl (2S)-pyrrolidine-2-carboxylate 
• 955-40-8 N-benzyl-L-proline ethyl ester 
• 118971-01-0 (S)-(-)-2-(1-methoxy-1-ethylpropyl)-pyrrolidine 

Downstream Products

• 229639-89-8 benzylacetone (S)-1-amino-2-(1'-methoxy-1'-ethylpropyl)pyrrolidine hydrazone 
• 118535-90-3 [(S)-2-Benzyloxy-hex-(Z)-ylidene]-[(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-amine 
• 118535-88-9 [(S)-2-Benzyloxy-3-phenyl-prop-(Z)-ylidene]-[(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-amine 
• 118535-86-7 [(S)-2-Benzyloxy-oct-(Z)-ylidene]-[(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-yl]-amine 
• 148432-23-9 (R)-2-[(E)-(S)-2-(1-Ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-hydroxy-nonanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 148432-20-6 (S,R)-(+)-1-[3-Hydroxy-5-methyl-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-hexylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine 
• 148432-22-8 (S,R)-(+)-1-[3-Hydroxy-1-(2,6-di-tert-butyl-4-methoxy-1-phenoxycarbonyl)-1-heptylideneamino]-2-(1-ethyl-1-methoxypropyl)pyrrolidine 
• 148432-32-0 (R)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-6-phenyl-hexanoic acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 148432-35-3 (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-(4-methoxy-phenyl)-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 148432-34-2 (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-p-tolyl-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 148432-33-1 (S)-4-Benzyloxymethoxy-2-[(E)-(S)-2-(1-ethyl-1-methoxy-propyl)-pyrrolidin-1-ylimino]-4-phenyl-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 

Relevant academic research and scientific papers

LARGE SCALE PREPARATION OF VERSATILE CHIRAL AUXILIARIES DERIVED FROM (S)-PROLINE

The synthesis of a variety of enantiomerically pure chiral auxiliaries based on (S)-proline and bearing sterically demanding side chains at the pyrrolidine moiety, such as the secondary amines (S)-3,5 and 7 and the hydrazines (S)-6, is described on a molar scale.As key step, the Grignard or RLi addition to the N-benzylated proline ester (S)-1 is used.