23589-80-2

Upstream product

• 19227-11-3 N'-hydroxy-2-phenylethanimidamide 
• 541-41-3 chloroformic acid ethyl ester 
• 105-58-8 Diethyl carbonate 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 5504-24-5 2-phenylacetamidine 
• 28180-29-2 3-benzyl-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 58599-01-2 3-benzyl-5-methoxy-1,2,4-oxadiazole 
• 57689-40-4 3-benzyl-4-N-n-propylcarbamyl-1,2,4-oxadiazolin-5-one 
• 57689-34-6 3-benzyl-4-isopropoxycarbonyl-1,2,4-oxadiazolin-5-one 
• 57689-35-7 3-benzyl-4-ethoxycarbonyl-1,2,4-oxadiazolin-5-one 
• 59174-09-3 4,5-dihydro-5-oxo-α-phenyl-1,2,4-oxadiazole-3-acetic acid 
• 28268-04-4 N-<2-Diaethylamino-aethyl>-phenylessigsaeure-amidoxim 
• 28268-03-3 N-Carboxymethyl-phenylessigsaeure-amidoxim 
• 28268-02-2 N-Methyl-phenylessigsaeure-amid-oxim 
• 28267-95-0 (3-benzyl-5-oxo-[1,2,4]oxadiazol-4-yl)-acetic acid ethyl ester 
• 741612-62-4 3-benzyl-4-(2-diethylamino-ethyl)-4H-[1,2,4]oxadiazol-5-one 
• 39741-08-7 3,3'-dibenzyl-4H,4'H-4,4'-carbonyl-bis-[1,2,4]oxadiazol-5-one 
• 24878-54-4 3-benzyl-4-phenyl-1,2,4-oxadiazol-5(4H)-one 

Relevant academic research and scientific papers

Copper-Catalyzed Selective N-Arylation of Oxadiazolones by Diaryliodonium Salts

Here, we report the method for copper-catalyzed N-arylation of diverse oxadiazolones by diaryliodonium salts under mild conditions in high yields (up to 92%) using available CuI as a catalyst. The developed method allows utilizing both symmetric and unsymmetric diaryliodonium salts bearing auxiliary groups such as 2,4,6-trimethoxyphenyl (TMP). We found that the steric effects in aryl moieties determined the chemoselectivity of N- and O-arylation of the 1,2,4-oxadiazol-5(4H)-ones. Mesityl-substituted diaryliodonium salts demonstrated the high potential as a selective arylation reagent. The structural study suggests that steric accessibility of N-atom in 1,2,4-oxadiazol-5(4H)-ones impact to arylation with sterically hindered diaryliodonium salts. The synthetic application of proposed method was also demonstrated on selective arylation of 1,3,4-oxadiazol-2(3H)-ones and 1,2,4-oxadiazole-5-thiol. (Figure presented.).

Rh(II)-Catalyzed Transannulation of 1,2,4-Oxadiazole Derivatives with 1-Sulfonyl-1,2,3-triazoles: Regioselective Synthesis of 5-Sulfonamidoimidazoles

An effective method for the synthesis of fully substituted 5-sulfonamidoimidazoles by Rh(II)-catalyzed transannulation of 1,2,4-oxadiazole derivatives with N-sulfonyl-1,2,3-triazoles is reported. The reaction works well with both aromatic 1,2,4-oxadiazoles and 1,2,4-oxadiazol-5-ones providing a flexible approach to N-(alkoxy/amino)carbonyl- and N-alkyl-substituted imidazoles. Both the disclosed reactions are completely regioselective and provide the first examples of a carbenoid-mediated transformation of N,N,O-heterocycles.

Studies of the cyclocondensation of o-aminophenyl-substituted ketoximes and amidoximes with carbonyl compounds giving quinazoline derivatives

Heating of o-amino-substituted ketoximes and amidoximes 3 with aldehydes and ketones gives the heterocyclic amidine- or quinazoline-N-oxides 5, respectively, from anthranilic acid amidoxime (3c) and diethyl carbonate the oxadiazolone 12 is formed. Thermol

1,2,4-Oxadiazolonylacetyl penicillins

1,2,4-Oxadiazolonylacetyl penicillins and cephalosporins of the general formula SPC1 Wherein A is either SPC2 R1 is hydrogen, lower alkyl or phenyl-lower alkyl; R2 is hydrogen, lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or p