28180-29-2

Upstream product

• 186581-53-3 diazomethane 
• 23589-80-2 3-benzyl-1,2,4-oxadiazol-5(4H)-one 
• 19227-11-3 N'-hydroxy-2-phenylethanimidamide 
• 74-88-4 methyl iodide 

Downstream Products

• 28268-02-2 N-Methyl-phenylessigsaeure-amid-oxim 
• 1427195-83-2 3-[(Z)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 1427198-14-8 2-methylpentan-2-yl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate 
• 1427197-78-1 3-[(Z)-({[6-(diethylamino)pyridin-2-yl]methoxy}imino)(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 1427196-25-5 4-methyl-3-{(Z)-phenyl[({6-[(1-phenylethyl)amino]pyridin-2-yl}methoxy)imino]methyl}-1,2,4-oxadiazol-5(4H)-one 
• 1427198-34-2 3-[(Z)-[({6-[(2-cyclohexylethyl)amino]pyridin-2-yl}methoxy)imino](phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 1427198-60-4 tert-butyl (2-cyclohexylethyl){6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate 
• 1427196-03-9 tert-butyl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate 
• 1427201-42-0 3-benzoyl-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 1427196-07-3 3-[(E)-{[(6-aminopyridin-2-yl)methoxy]imino}(phenyl)methyl]-4-methyl-1,2,4-oxadiazol-5(4H)-one 
• 1427196-00-6 butyl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate 

Relevant academic research and scientific papers

Rh(II)-Catalyzed Transannulation of 1,2,4-Oxadiazole Derivatives with 1-Sulfonyl-1,2,3-triazoles: Regioselective Synthesis of 5-Sulfonamidoimidazoles

An effective method for the synthesis of fully substituted 5-sulfonamidoimidazoles by Rh(II)-catalyzed transannulation of 1,2,4-oxadiazole derivatives with N-sulfonyl-1,2,3-triazoles is reported. The reaction works well with both aromatic 1,2,4-oxadiazoles and 1,2,4-oxadiazol-5-ones providing a flexible approach to N-(alkoxy/amino)carbonyl- and N-alkyl-substituted imidazoles. Both the disclosed reactions are completely regioselective and provide the first examples of a carbenoid-mediated transformation of N,N,O-heterocycles.

Tf2NH-catalyzed formal [3 + 2] cycloaddition of oxadiazolones with ynamides: a simple access to aminoimidazoles

Oxadiazolones are first employed as the three-atom coupling partners in the Tf2NH-catalyzed cycloaddition with ynamides. This formal [3 + 2] cycloaddition allows a rapid synthesis of aminoimidazoles with a broad substrate scope. The approach also features a metal-free catalytic cycloaddition process, which may find applications in the synthesis of bioactive molecules. Besides, the resulting N-methyl products can further be readily converted to free N-H aminoimidazoles.

1,2,4-Oxadiazolonylacetyl penicillins

1,2,4-Oxadiazolonylacetyl penicillins and cephalosporins of the general formula SPC1 Wherein A is either SPC2 R1 is hydrogen, lower alkyl or phenyl-lower alkyl; R2 is hydrogen, lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or p