23590-40-1Relevant academic research and scientific papers
In situ generation of 1-propyne: A useful introduction of 1-propyne on unsaturated halogenated compounds through the sonogashira reaction
Abraham, Estelle,Suffert, Jean
, p. 328 - 330 (2002)
Reaction of (E/Z)-1-bromopropene with exactly 1.42 equivalents of nBuLi followed by addition of water produces in situ a THF solution of propyne. Addition of a vinylic or aromatic halogenated substrates, Pd(PPh3)2Cl2, CuI and an amine to this solution give high yield of the corresponding coupling product beating a propyne moiety. This practical procedure avoids the use of expensive and inflammable propyne gas which need a special apparatus for bubbling it into the reaction flask.
