2360-22-7

Basic information

• Product Name: 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95
• Synonyms: 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95;1-Methyl-1H-Benzimidazole-2-Thio;2H-Benzimidazole-2-thione,1,3-dihydro-1-methyl-(9CI);1-methyl-1H-benzimidazole-2-thiol(SALTDATA: FREE);1,3-Dihydro-1-Methyl-2H-benziMidazole-2-thione;2-Mercapto-1-Methylbenzo[d]iMidazole;2-Mecapto-1-methylbenzimidazole;1-Methyl-1H-benzo[d]iMidazole-2-thiol
• CAS NO: 2360-22-7
• Molecular Formula: C₈H₈N₂S
• Molecular Weight: 164.231
• Product Categories: BENZIMIDAZOLE;Imidazol&Benzimidazole;Benzimidazoles;Building Blocks;Heterocyclic Building Blocks
• Mol File: 2360-22-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 193-197 °C(lit.)
• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 116.3 °C
• Appearance: /
• Density: 1.33 g/cm³
• CAS DataBase Reference: 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95(2360-22-7)
• EPA Substance Registry System: 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95(2360-22-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2360-22-7(Hazardous Substances Data)

Usage

General Description

1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95 is a chemical compound that falls under the category of benzimidazole derivatives. It is a yellow crystalline powder with a molecular formula C8H8N2S and a molecular weight of 164.23 g/mol. This chemical is commonly used as a corrosion inhibitor and as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its use in the production of rubber accelerators and antioxidants. Additionally, 1-METHYL-1H-BENZIMIDAZOLE-2-THIOL 95 is utilized in the manufacture of dyes, pigments, and other organic chemicals. As a thiol compound, it possesses strong nucleophilic properties and is often employed in organic synthesis reactions.

Upstream product

• 4344-61-0 1-methyl-2-(methylthio)-1H-benzimidazole 
• 61078-14-6 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole 
• 5533-38-0 1-methyl-1H-benzo[d]imidazole-2-sulfonic acid 

Downstream Products

• 856810-90-7 2-(1-methyl-1H-benzimidazol-2-ylmercapto)-propionic acid 
• 854855-87-1 2-(1-methyl-1H-benzimidazol-2-ylmercapto)-butyric acid 
• 159222-24-9 (1-methyl-1H-benzimidazol-2-ylmercapto)-acetic acid 
• 73384-55-1 anhydro-2-Hydroxy-10-methyl-4-oxo-3-phenylbenzo-4H-imidazo<2,1-b><1,3>thiazinium hydroxide 
• 85218-43-5 1-methyl-2-(4'-nitrophenacylthio)benzimidazole 
• 85218-42-4 2-(4'-bromophenacylthio)-1-methylbenzimidazole 
• 85218-44-6 2-(4'-methoxyphenacylthio)-1-methylbenzimidazole 
• 2622-63-1 1-methyl-2-phenylbenzimidazole 
• 46818-46-6 1-methyl-1H-benzo[d]imidazol-2-yl phenyl sulfide 
• 106-48-9 4-chloro-phenol 

Relevant articles and documents

Methylenation for Aldehydes and Ketones Using 1-Methylbenzimidazol-2-yl Methyl Sulfone

The methylenation reagent 1-methylbenzimidazol-2-yl methyl sulfone 2 reacts with various aldehydes and ketones in the presence of t-BuOK (room temperature, 1 h) in dimethylformamide to give the corresponding terminal alkenes generally in high yields. For sensitive substrates, the reaction is better carried out at low temperature using sodium hexamethyldisilazide in 1,2-dimethoxyethane. The byproduct is easily removed from the products, and the reaction conditions are mild and practical. Reagent 2 can be easily prepared from commercially available 2-mercaptobenzimidazole 5 in 95% yield without any expensive reagents.

Imidazole compounds and their use as transglutaminase inhibitors

Imidazole compounds including imidazoles and imidazolium salts, and their use as transglutaminase inhibitors are disclosed.