61078-14-6

Basic information

• Product Name: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole
• Synonyms: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole;1-Methyl-2-(methylsulfonyl)benzimidazole;1H-Benzimidazole, 1-methyl-2-(methylsulfonyl)-
• CAS NO: 61078-14-6
• Molecular Formula: C₉H₁₀N₂O₂S
• Molecular Weight: 210.2529
• EINECS: -0
• Mol File: 61078-14-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 132.0 to 136.0 °C
• Appearance: /
• CAS DataBase Reference: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole(61078-14-6)
• EPA Substance Registry System: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole(61078-14-6)

Safety Data

• Hazardous Substances Data: 61078-14-6(Hazardous Substances Data)

Usage

General Description

1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole is a chemical compound with a molecular formula of C9H10N2O2S. It is a derivative of benzimidazole, and it contains a methyl group and a methylsulfonyl group attached to the benzene ring. 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole is used in the pharmaceutical industry for its potential therapeutic properties, including its ability to inhibit enzymes and modulate biological pathways. It has been studied for its potential applications in treating various diseases and conditions, including cancer and inflammation. The methylsulfonyl group in this compound may contribute to its pharmacological activities, making it a molecule of interest for further research and development in drug discovery.

Upstream product

• 134469-07-1 Benzimidazol-2-thiol 
• 57159-81-6 2-(methylsulfonyl)-1H-benzo[d]imidazole 
• 74-88-4 methyl iodide 
• 4344-61-0 1-methyl-2-(methylthio)-1H-benzimidazole 
• 7732-18-5 water 
• 7152-24-1 2-methylsulfanylbenzimidazole 
• 74-87-3 methylene chloride 

Downstream Products

• 27097-08-1 N-benzyl-1-methyl-1H-benzo[d]imidazol-2-amine 
• 6888-79-5 4-bromo-α-methylstyrene 
• 875-72-9 2-methylideneadamantane 
• 159635-49-1 tert-butyl 4-methylidenepiperidine-1-carboxylate 
• 28884-75-5 1,3,3-trimethyl-2-(3-methyl-1,3-butadienyl)-1-cyclohexene 
• 119433-76-0 (1S,4R)-1-isopropyl-4-methyl-2-methylene-cyclohexane 
• 1073-67-2 4-vinylbenzyl chloride 
• 6380-23-0 3,4-dimethoxystyrene 
• 826-74-4 1-vinylnaphthalene 
• 62108-28-5 4,8-dimethylnona-1,7-diene 
• 1849-01-0 1-methyl-2-benzimidazolone 
• 17088-21-0 1-vinylpyrene 
• 769-25-5 2,4,6-trimethylstyrene 
• 1515-78-2 buta-1,3-dien-1-ylbenzene 

Relevant articles and documents

Metal-Free Aminomethylation of Aromatic Sulfones Promoted by Eosin Y

A metal-free α-aminomethylation of heteroaryls promoted by eosin Y under green light irradiation is reported. A large variety of α-trimethylsilylamines as precursor of α-aminomethyl radical species were engaged to functionalize sulfonyl-heteroaryls following a Homolytic Aromatic Substitution (HAS) pathway. This method has provided a range of α-aminoheteroaryl compounds including a functionalized natural product. The mechanism of this late-stage functionalization of aryls was investigated and suggests the formation of a sulfonyl radical intermediate over a reductive quenching cycle.

Practical Methylenation Reaction for Aldehydes and Ketones Using New Julia-Type Reagents

A new Julia-type methylenation reagent, 1-methyl-2-(methylsulfonyl)benzimidazole (1e), reacts with a variety of aldehydes and ketones in the presence of either NaHMDS (-55 °C to rt) or t-BuOK (rt, 1 h) in DMF to give the corresponding terminal alkenes in high yields. The byproducts are easily removed, and the reaction conditions are mild and practical.

Substituted arylsulfonamides and benzamides

This invention relates to substituted arylsulfonamides and benzamides possessing aniarrhythmic activity, to pharmaceutical compositions and to methods for production thereof.