23602-65-5

Usage

Uses

Used in Chemical Synthesis:
Benzaldehyde, 2,3,5-trichloro-6-hydroxyis used as a reactant in the synthesis of various organic compounds, particularly trichlorophenols. These trichlorophenols serve as potential biomarkers for occupational exposure, which can be crucial in assessing the health risks associated with certain工作环境 (work environments) and in developing preventive measures.
Used in Environmental Monitoring:
In the Environmental Monitoring Industry, Benzaldehyde, 2,3,5-trichloro-6-hydroxyis used as a chemical intermediate for the production of compounds that can be employed as indicators of environmental contamination. The detection of trichlorophenols in environmental samples can provide valuable information about the presence of specific pollutants and help in the assessment of environmental quality and human health risks.
Used in Research and Development:
In the Research and Development Industry, Benzaldehyde, 2,3,5-trichloro-6-hydroxycan be utilized as a starting material for the development of new compounds with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science. Its unique structure makes it an interesting candidate for the design and synthesis of novel molecules with specific properties and functions.
Used in Analytical Chemistry:
In the Analytical Chemistry Industry, Benzaldehyde, 2,3,5-trichloro-6-hydroxymay be used as a reference compound or a standard for the calibration of analytical instruments and methods. Its distinct chemical properties can make it a valuable tool for the accurate determination of other compounds in complex mixtures, contributing to the advancement of analytical techniques and the quality of chemical analysis.

Upstream product

• 67-66-3 chloroform 
• 95-95-4 2,4,5-trichlorophenol 
• 50-00-0 formaldehyd 

Downstream Products

• 78335-98-5 2-(2-Amino-ethyl)-3,4,6-trichloro-phenol 
• 78335-93-0 2-(2-amino-1-hydroxyethyl)-3,4,6-trichlorophenol hydrochloride 
• 78335-97-4 2-(2-nitroethenyl)-3,4,6-trichlorophenol 
• 568579-79-3 methyl 3-(2-hydroxy-3,5,6-trichlorophenyl)propanoate 
• 395545-65-0 3-(2-hydroxy-3,6-dichlorophenyl)-propanoic acid 
• 24581-94-0 3,4,6-Trichlor-2-formyl-phenoxyessigsaeure-methylester 
• 78335-96-3 2-(1-hydroxy-2-nitroethyl)3,4,6-trichlorophenol 

Relevant academic research and scientific papers

Non-metallocene compounds, method for the production thereof and use of the same for the polymerisation of olefins

The invention relates to a method for producing special transition metal compounds, to novel transition metal compounds and to the use of the same for the polymerisation of olefins.

Development and evaluation of an immunoassay for biological monitoring chlorophenols in urine as potential indicators of occupational exposure

Trichlorophenols (TCP) eliminated by the urine can be considered as potential biomarkers of exposure of many chemicals (chlorophenols, chlorophenoxy acid herbicides, prochloraz, lindane, hexachlorobenzene, etc). Highthroughput screening methods are necessary to carry out efficient monitoring programs that may help to prevent certain occupational health diseases. For this purpose, an indirect enzyme-linked immunosorbent assay (ELISA) for 2,4,6-trichlorophenol detection has been developed using polyclonal antisera raised against 3-(3-hydroxy-2,4,6-trichlorophenyl)propanoic acid (hapten 5) covalently coupled by the mixed anhydride (MA) method to keyhole limpet hemocyanin (KLH). The indirect ELISA uses a heterologous coating antigen prepared by conjugation of 3-(2-hydroxy-3,6-dichlorophenyl)propanoic acid (hapten 4) to bovine serum albumin (BSA) using the active ester (AE) method. The optimum hapten density for the coating antigen was found to be 3 mol of hapten/mol of protein. The assay shows a limit of detection of 0.245 ± 0.116 μg L-1, and it is performed on 96-well microtiter plates in about 1.5 h. The ELISA reported recognizes on a much less extent other chlorinated phenols, such as 2,3,4,6-tetrachlorophenol (2,3,4,6-TtCP, 21%), 2,4,5-TCP (12%) and 2,3,5-TCP (15%); however, brominated phenols (BP) are even more recognized than the corresponding chlorinated analogues (ex. 2,4,6-TBP, 710%; 2,4-DBP, 119%). With the aim of finding an explanation for this behavior, theoretical calculations have been performed for those and other halogenated phenols (2,4,6-triiodophenol and 2,4,6-trifluorophenol) to clarify which physicochemical parameter can explain better the recognition pattern observed. Finally, the assay has been adapted to the analysis of urine samples. The studies have shown that a limit of detection of 1 μg L-1 can be accomplished on this biological matrix by combining the ELISA procedure with a C18 solid-phase extraction method.

2-(Aminomethyl)phenols, a New Class of Saluretic Agents. 3. Effects of Functional Group Reorientation and Modification

A series of modified 2-(aminomethyl)phenols was synthesized and tested orally in rats for saluretic and diuretic effects.Intravenous dog data are included as supplementary material to show that the diuretic responses, or lack thereof, may be obtained in a second species.Reorientation of the 2-(aminomethyl) group either meta or para to the hydroxyl substituent resulted in loss of diuretic effects.Similarly, replacement of either the phenolic hydroxyl or the aminomethyl group with other functional moieties substantially diminished saluretic effects.