236109-55-0Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of new 11H-triazolo[4,5- c][2,3]benzodiazepines
Chimirri, Alba,Bevacqua, Francesca,Gitto, Rosaria,Quartarone, Silvana,Zappala, Maria,De Sarro, Angela,Maciocco, Lisa,Biggio, Giovanni,De Sarro, Giovambattista
, p. 203 - 212 (2007/10/03)
Starting from the corresponding 3,5-dihydro-4H-2,3-benzodiazepin-4- ones, new 11H-triazolo[4,5-c]-[2,3]benzodiazepines were synthesized and tested for anticonvulsant activity. Seizures were evoked both by means of auditory stimulation in DBA/2 mice and by pentylenetetrazole or maximal electroshock in Swiss mice. The pharmacological results revealed that the new tricyclic derivatives show less activity than their precursors.
