23632-41-9

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 103519-90-0 3-(4-bromophenyl)-2-methylacrylic acid ethyl ester 
• 563-52-0 2-chloro-3-butene 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 123-38-6 propionaldehyde 

Downstream Products

• 186497-72-3 2-methyl-3-(4-bromophenyl)propanol 
• 1428319-20-3 (E)-3-(4-bromophenyl)-1-cyclohexenyl-2-methylprop-2-en-1-ol 
• 1428319-38-3 (5R,6R)-5-(4-bromophenyl)-6-methyl-3,4,5,6-tetrahydrocyclopenta[b]pyran-7(2H)-one 
• 1428319-57-6 (5R,6S)-5-(4-bromophenyl)-6-methyl-3,4,5,6-tetrahydrocyclopenta[b]pyran-7(2H)-one 
• 1428319-32-7 (E)-3-(4-bromophenyl)-1-(cyclohex-1-en-1-yl)-2-methylprop-2-en-1-one 
• 1345114-63-7 (E)-3-(4-bromophenyl)-1-(3,4-dihydro-2H-pyran-6-yl)-2-methylprop-2-en-1-one 
• 1428319-53-2 (5R,6S)-diisopropyl 1-(6-methyl-7-oxo-5-(4-bromophenyl)-2,3,4,5-hexahydrocyclopenta[b]pyran-6-yl)hydrazine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

Copper-Catalyzed Stereospecific Hydroboration of Internal Allylic Alcohols

An effective Cu-catalyzed stereospecific hydroboration of aliphatic and aromatic 1,1,2-trisubstituted internal allylic alcohols has been reported. This reaction proceeds via a silyl ether transient protection of allylic alcohols and subsequent stereospecific hydroboration. Followed by an oxidative workup, an array of acyclic, cyclic, and heterocyclic 1,3-diols was synthesized in good to excellent yields with good functional group tolerance and excellent diastereomeric ratios (> 20:1).

Process for the Preparation of Idnanones

A process of forming compounds of formula I comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.

Enantioselective Nazarov Cyclizations Catalyzed by an Axial Chiral C6F5-Substituted Boron Lewis Acid

A chiral variant of B(C6F5)3 with a 3,3′-disubstituted binaphthyl backbone is shown to catalyze Nazarov cyclizations with high levels of enantio- and diastereocontrol. The parent B(C6F5)3 a

Traceless sulfone linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α-β-unsaturated carbonyl compounds

The highly efficient and convenient protocol to prepare diverse α,β-unsaturated aldehydes, ketones, and acids via the parallel solid-phase synthesis is developed. The key sulfone linker cleavage strategy is performed by ozonolysis to generate a carbonyl moiety followed by base-mediated polymer-bound sulfinate elimination to release our desired molecules from the resin. All α,β-unsaturated carbonyl compounds are prepared in good purities and yields without further purification.

Total synthesis of LFA-1 antagonist BIRT-377 via organocatalytic asymmetric construction of a quaternary stereocenter

(Chemical Equation Presented) A catalytic route for enantioselective total synthesis of cell adhesion inhibitor BIRT-377 is described. The quaternary stereocenter was constructed through L-proline-derived, tetrazole-catalyzed direct asymmetric α-amination