23632-73-7

Basic information

• Product Name: Butanoic acid, 4-amino-4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-
• CAS NO: 23632-73-7
• Molecular Formula: C12H14N2O5
• Molecular Weight: 266.254
• Mol File: 23632-73-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-amino-4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-amino-4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(23632-73-7)
• EPA Substance Registry System: Butanoic acid, 4-amino-4-oxo-3-[[(phenylmethoxy)carbonyl]amino]-, (S)-(23632-73-7)

Safety Data

• Hazardous Substances Data: 23632-73-7(Hazardous Substances Data)

Upstream product

• 1152-61-0 N-Cbz-L-Asp 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 64263-86-1 N²-benzyloxycarbonyl-DL-isoasparagine 
• 4668-43-3 (S)-3-(benzyloxycarbonylamino)-4-ethoxy-4-oxobutanoic acid 

Downstream Products

• 97533-36-3 N²-benzyloxycarbonyl-L-isoasparagine benzyl ester 
• 31883-81-5 (S)-methyl 3-(benzyloxycarbonylamino)-3-cyanopropanoate 
• 178247-96-6 C₆₀H₆₉Cl₆N₃O₂₄ 
• 178247-97-7 C₅₄H₆₇N₃O₂₀ 
• 178248-38-9 (S)-3-Benzyloxycarbonylamino-succinamic acid carboxymethyl ester 
• 51163-34-9 methyl (S)-4-amino-3-(((benzyloxy)carbonyl)amino)-4-oxobutanoate 
• 87023-97-0 Z-L-Asp-(DMPir)NH₂ 
• 129835-82-1 Z-isoAsn-Leu-Thr-NH₂ 
• 7436-73-9 Carbobenzoxy-β-cyan-β-L-alanin 
• 120581-57-9 S-benzyl-N-(N²-benzyloxycarbonyl-L-isoasparaginyl)-L-cysteine benzyl ester 

Relevant articles and documents

Enzymatic C-terminal amidation of amino acids and peptides

Herein, we describe two versatile and high yielding enzymatic approaches for the conversion of semi-protected amino acid and peptidyl C-terminal α-carboxylic acids into their corresponding amides. In the first approach, the lipase Candida antarctica lipase-B (Cal-B), and in the second approach, the protease Subtilisin A, are used, respectively. We found that by using the ammonium salt of the α-carboxylic acid instead of separate ammonia sources, the enzymatic amidation reactions proceeded much faster without side reactions and gave near to quantitative yields of products.

Regioselective amidation of aspartic and glutamic acid

The synthesis of N-protected aspartic 1-amide and glutamic 1-amide from aspartic and glutamic acids via regioselective amidation of intermediate 5-oxazolidinone derivatives with aqueous ammonia or amine is described.