2365-20-0Relevant academic research and scientific papers
Synthesis and in vitro antimicrobial and antitumoral screening of novel lipophilic isoniazid analogues. VI
Vigorita,Ottana,Maccari,Monforte,Bisignano,Pizzimenti
, p. 267 - 276 (2007/10/03)
Various kinds of lipophilic analogues of isonicotinic acid hydrazide (Isoniazid) were synthesized and in vitro explored in a search for antimycobacterial agents with extended activity spectrum against pathogens responsible for the AIDS-associated diseases. The primary in vitro screening showed that a) isonicotinoylhydrazones 1a, 1b, 1d, 1e are more active than the parent drug against non-tubercular mycobacteria (MIC ranging between 0.5 and 4 μg/ml), b) isonicotinohydrazides 6b and 6e display interesting antibacterial activity on some Gram + and Gram - strains, and c) trifluoromethyl-containing compounds 1a and 2c inhibit the growth of several human tumor cell lines at doses between 10-5 and 10-6 M. On the contrary, none of the tested analogues significantly counteracts the cytopathogenicity induced by HIV and HSV viruses.
