2365-26-6

Basic information

• Product Name: 1-formylisoquinoline thiosemicarbazone
• Synonyms: 1-formylisoquinoline thiosemicarbazone;1-Isoquinolinecarbaldehyde thiosemicarbazone;IQ-1
• CAS NO: 2365-26-6
• Molecular Formula: C11H10 N4 S
• Molecular Weight: 230.31
• Mol File: 2365-26-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 447.3°Cat760mmHg
• Flash Point: 224.3°C
• Appearance: /
• Density: 1.2608 (rough estimate)
• Vapor Pressure: 3.4E-08mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• CAS DataBase Reference: 1-formylisoquinoline thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-formylisoquinoline thiosemicarbazone(2365-26-6)
• EPA Substance Registry System: 1-formylisoquinoline thiosemicarbazone(2365-26-6)

Safety Data

• Hazardous Substances Data: 2365-26-6(Hazardous Substances Data)

Usage

Uses

IQ 1 disrupts Wnt signaling. IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription.

InChI:InChI=1/C11H10N4S/c12-11(16)15-14-7-10-9-4-2-1-3-8(9)5-6-13-10/h1-7H,(H3,12,15,16)/b14-7-

Relevant articles and documents

Potential antitumor agents. I. A series of 5-substituted 1-formylisoquinoline thiosemicarbazones.

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