2365-80-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid are used as building blocks for the development of new pharmaceuticals. The trifluoromethyl group enhances the efficacy and stability of the resulting drugs, making them more potent and longer-lasting.
Used in Chemical Research:
In chemical research, 2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid are employed as key components in the synthesis of complex organic molecules. Their unique structure allows for the creation of novel compounds with potential applications in various fields.
Used in Agrochemical Synthesis:
2-Amino-5,5,5-trifluoropentanoic acid, 2-Amino-5,5,5-trifluorovaleric acid are used as intermediates in the synthesis of agrochemicals. Their incorporation into these products can lead to the development of more effective and stable pesticides and other agricultural chemicals.
Used in Specialty Chemicals:
These compounds are also utilized in the production of specialty chemicals, where their unique properties can be harnessed to create new materials with specific characteristics for use in various applications.

Upstream product

• 23809-63-4 5-(3,3,3-trifluoropropyl)imidazolidine-2,4-dione 
• 96563-56-3 N-acetyl-5,5,5-trifluoronorvaline 
• 118311-19-6 5,5,5-Trifluoro-2-[(Z)-hydroxyimino]-pentanoic acid 
• 120097-66-7 diethyl α-(N-acetylamino)-α-(3,3,3-trifluoropropyl)malonate 
• 118311-18-5 5,5,5-trifluoro-2-oxopentanoic acid 
• 118325-20-5 5,5,5-Trifluoro-2-oxo-pentanoic acid tert-butylamide 
• 1859-47-8 2-(benzylamino)-5,5,5-trifluoropentanoic acid 
• 406-87-1 4,4,4-trifluorobutanal 
• 143-33-9 sodium cyanide 

Downstream Products

• 1859-47-8 2-(benzylamino)-5,5,5-trifluoropentanoic acid 
• 122565-28-0 (S)-2-amino-5,5,5-trifluoropentanoic acid 
• 122565-29-1 (2R)-2-amino-5,5,5-trifluoropentanoic acid 

Relevant academic research and scientific papers

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y═C, or substituted diene fused to Y when Y═C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.

PALLADIUM-CATALYZED DOUBLE CARBONYLATION OF ALKYL IODIDES BEARING PERFLUOROALKYL GROUP

Double carbonylation of 1-perfluoroalkyl substituted 2-iodoalkanes are effectively catalyzed by palladium complexes in the presence of primary or secondary amines leading to the formation of the corresponding α-keto amides in good yields.

New and Effective Routes to Fluoro Analogues of Aliphatic and Aromatic Amino Acids

New and efficient syntheses of 4,4,4-trifluorovaline (1), 5,5,5-trifluoronorvaline (2), 5,5,5-trifluoroleucine (5), 6,6,6-trifluoronorleucine (6), 4,5,6,7-tetrafluorotryptophan (25), and α-(trifluoromethyl)-β-alanine are studied.Trifluorovaline (1) and trifluoronorvaline (2) are synthesized through amidocarbonylation of 2-(trifluoromethyl)propanal (2-TFMPA) and 3-(trifluoromethyl)propanal (3-TFMPA), respectively, followed by hydrolysis.Trifluoroleucine (5) and trifluoronorleucine (6) are synthesized by using modified Erlenmeyer's azlactone method from 2-TFMPA and 3-TFMPA, respectively. (S)- and (R)-trifluoronorvalines and trifluoronorleucines with high enantiomeric purities (95-100percent ee) are obtained through enzymatic optical resolution of N-acetyltrifluoronorvaline (4) and N-acetyltrifluoronorleucine (17) with the use of a porcine kidney acylase I.Optically active trifluoronorleucine is also obtained via the asymmetric hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (10a-Z) with a chiral rhodium catalyst, ClO4, followed by hydrolysis.Unexpectedly high diastereoselectivities (80-87percent ee) are observed in the hydrogenation of (Z)-N-benzoyldehydrotrifluoroleucine ethyl ester (11b) and (Z)-N-benzoyl-4-(pentafluorophenyl)dehydronorvaline (14-Z) over palladium/carbon. 4,5,6,7-Tetrafluorotryptophan (25) and 4,5,6,7-tetrahydrotryptamine (30) are synthesized from 3-formyl-4,5,6,7-tetrafluoroindole (22a) in 51percent (four steps) and 83percent (two steps) overall yields, respectively. 4,5,6,7-Tetrafluoroindoleacetic acid (28) is obtained from 1-acetyl-3-(acetoxymethyl)-4,5,6,7-tetrafluoroindole (23a) in four steps in 65percent overall yield.The 3-formyl- and 1-acetyl-3-(acetoxymethyl)tetrafluoroindoles (22a, 23a) are prepared through selenium dioxide oxidation of 1-acyl-3-methyl-4,5,6,7-tetrafluoroindole (21), which is obtained via the cyclization of a Schiff base of 2-(pentafluorophenyl)propanal (2-PFPPA), in good yields.