23654-93-5

Usage

Uses

Used in Organic Synthesis:
2-(ethenylsulfonyl)naphthalene is used as a building block for the creation of various functional groups in organic synthesis. Its unique structure and reactivity allow it to be a key component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
2-(ethenylsulfonyl)naphthalene is used as a starting material for the development of new pharmaceutical compounds. Its potential use in medicinal applications is being studied due to its unique structure and reactivity, which may contribute to the discovery of novel therapeutic agents.

Upstream product

• 100953-47-7 naphthalen-2-yl(vinyl)sulfane 
• 100519-04-8 2-(naphthalene-2-sulfonyl)-ethanol 
• 5586-15-2 bis(2-naphthyl)disulfide 
• 1826-67-1 vinyl magnesium bromide 
• 420-12-2 thirane 
• 63735-42-2 sodium naphthalen-2-ylsulfinate 
• 106-93-4 ethylene dibromide 
• 93-11-8 2-Naphthalenesulfonyl chloride 
• 91-60-1 2-Naphthalenethiol 

Downstream Products

• 102018-99-5 1-(naphthalene-2-sulfonyl)-2-(toluene-4-sulfonyl)-ethane 
• 887917-89-7 methyl (2R,4S,5R)-4-(2-naphthyl)sulfonyl-5-phenylpyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

Metal-free visible-light-promoted C(sp3)-H functionalization of aliphatic cyclic ethers using trace O2

Presented is a light-promoted C-C bond forming reaction yielding sulfone and phosphate derivatives at room temperature in the absence of metals or photoredox catalyst. This transformation proceeds in neat conditions through an auto-oxidation mechanism which is maintained through the leaching of trace amounts of O2 as sole green oxidant. This journal is

Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts

Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.

Safe and Metal-Free Synthesis of 1-Alkenyl Aryl Sulfides and Their Sulfones from Thiiranes and Diaryliodonium Salts

A series of 1-alkenyl aryl sulfides was synthesized from thiiranes and diaryliodonium salts in tetrahydrofuran in the presence of potassium tert -butoxide. The proposed reaction mechanism involves generation of benzynes from the diaryliodonium salts in the presence of the base. Then, nucleophilic attack of the benzynes by thiiranes, followed by hydrogen abstraction and ring opening of the generated thiiranium intermediates, provides the sulfides. These sulfides were further oxidized with performic acid to the corresponding sulfones. The current method provides a metal-free and safe method for the preparation of 1-alkenyl aryl sulfides and their sulfones.

Copper(I)-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides with vinyl sulfones

The combination of copper(I)-Taniaphos (5 mol%) is an efficient Lewis acid catalyst for the promotion of the asymmetric 1,3-dipolar cycloaddition of azomethine ylides to aryl vinyl sulfones, providing 3-sulfonylpyrrolidines in good yields and with nearly

Catalytic enantioselective 1,3-dipolar cycloaddition of azomethine ylides with vinyl sulfones

A general protocol for the enantioselective catalytic 1,3-dipolar cycloaddition of azomethine ylides with aryl vinyl sulfones is described. Nearly complete exo selectivity and enantioselectivities up to 85% ee are attained with Cu(CH3CN)4