23669-24-1Relevant academic research and scientific papers
Methyl-laudanosine: A new pharmacological tool to investigate the function of small-conductance Ca2+-activated K+ channels
Scuvee-Moreau, Jacqueline,Liegeois, Jean-Francois,Massotte, Laurent,Seutin, Vincent
, p. 1176 - 1183 (2002)
Small-conductance Ca2+-activated K+ channels (SK channels) underlie the prolonged postspike afterhyperpolarization (AHP) observed in many central neurons and play an important role in modulating neuronal activity. However, a lack of
Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers
Graulich,Mercier,Scuvee-Moreau,Seutin,Liegeois
, p. 1201 - 1209 (2007/10/03)
Neuronal action potentials are followed by an afterhyperpolarisation (AHP), which is mediated by small conductance Ca2+-activated K+ channels (SK channels or KCa2 channels). This AHP plays an important role in regulating neuronal act
