2367-91-1

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C6H3ClF2/c7-5-3-4(8)1-2-6(5)9/h1-3H

Upstream product

• 540-36-3 para-difluorobenzene 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 60-29-7 diethyl ether 
• 108-90-7 chlorobenzene 

Downstream Products

• 655-12-9 4'-chloro-2',5'-difluoroacetophenone 
• 656-19-9 4-Chlor-2,5-difluor-styrol 
• 655-11-8 Methyl-<4-chlor-2,5-difluor-phenyl>-carbinol 
• 578-28-9 1-Chloro-2,5-difluoro-4-nitrobenzene 
• 224168-12-1 ethyl (4-chloro-3,6-difluoro-2-nitrophenyl)carbamate 

Relevant academic research and scientific papers

Reactions of aromatic compounds with xenon difluoride

Reactions of substituted benzenes C6H5R (R = Me, F, Cl, Br, CF3, NO2) with xenon difluoride in the presence of boron trifluoride–diethyl ether complex in weakly acidic (1,1,1,3,3-pentafluorobutane) and weakly basic media (acetonitrile) have been studied. These reactions lead to the formation of fluorobenzene derivatives FC6H4R (isomer mixture) together with isomeric difluorobenzenes and fluorinated and non-fluorinated biphenyls. The results have been compared with previously reported data obtained in other solvents using other catalysts.

N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics

N-Halosuccinimides (NXS, 1) are efficiently activated in trifluoromethanesulfonic acid and BF3-H2O, allowing the halogenations of deactivated aromatics. Because BF3-H2O is more economic, easy to prepare, nonoxidizing, and offers sufficiently high acidity (-H0 ≈ 12, only slightly lower than that of trifluoromethanesulfonic acid), an efficient new electrophilic reagent combination of NXS/BF3-H2O has been developed. DFT calculations at the B3LYP/6-311++G**//B3LYP/6-31G* level suggest that protonated N-halosuccinimides undergo further protosolvation at higher acidities to reactive superelectrophilic species capable either in the transfer of X+ from the protonated forms of NXS to the aromatic substrate or in forming a highly reactive and solvated X+ which would readily react with the aromatic substrates. Structural aspects of the BF 3-H2O complex have also been investigated.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Procedure for the preparation of N-cyclopropyl-4-fluoroanilines

Procedure for the preparation of N-cyclopropyl-4-fluoroanilines of formula I. By selective reaction of II with cyclopropylamine, piperazines or pyrrolidines, III is obtained. Its acetylation and reduction yields IV which by de-amination leads to I. R1 is