23671-38-7Relevant academic research and scientific papers
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2
Tsai, Wan-Chen,Gilbert, Nathan C.,Ohler, Amanda,Armstrong, Michelle,Perry, Steven,Kalyanaraman, Chakrapani,Yasgar, Adam,Rai, Ganesha,Simeonov, Anton,Jadhav, Ajit,Standley, Melissa,Lee, Hsiau-Wei,Crews, Phillip,Iavarone, Anthony T.,Jacobson, Matthew P.,Neau, David B.,Offenbacher, Adam R.,Newcomer, Marcia,Holman, Theodore R.
, (2021/09/10)
Human epithelial 15-lipoxygenase-2 (h15-LOX-2, ALOX15B) is expressed in many tissues and has been implicated in atherosclerosis, cystic fibrosis and ferroptosis. However, there are few reported potent/selective inhibitors that are active ex vivo. In the c
Method for preparing cyclic thiourea compound
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Paragraph 0017-0018, (2021/12/07)
The method comprises the following steps: suspending metal hydride in anhydrous THF, dropwise adding ring thiourea in the stirring process, stirring at room temperature after completion of stirring, stirring at room temperature, TLC monitoring reaction co
New bis(mercaptoimidazolyl)(pyrazolyl)borate ligands and their zinc complex chemistry
Shu, Mouhai,Walz, Rainer,Wu, Biao,Seebacher, Jan,Vahrenkamp, Heinrich
, p. 2502 - 2511 (2007/10/03)
Nine new tripodal NS2 ligands of the bis(mercaptoimidazolyl)(pyrazolyl)borate type with varying 3-R-mercaptoimidazolyl moieties were prepared as their potassium salts. Treatment with zinc salts yielded the complex types L·Zn-Cl, L·Zn-I, L·Zn-ONO2, L·Zn-OClO3 and [L·Zn(imidazole)]ClO4. Attempts at the formation of L·Zn-OH or cationic L·Zn complexes resulted in dismutation and formation of ZnL2 complexes. Hydrolytic destruction yielded one [OZn4(thiooimidazolate)6] complex. The ZnS2NO coordination which is present in the enzyme-substrate complex of alcohol dehydrogenase could be successfully modelled by an [L·Zn(C2H5OH)]+ complex. The L·Zn-X complexes showed very low catalytic activity in the dehydrogenation of 2-propanol or the hydrogenation of p-nitrobenzaldehyde. The new compounds were identified by a total of 12 structure determinations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
One-pot preparation of 1-substituted imidazole-2-thione from isothiocyanate and amino acetal
Matsuda, Koyo,Yanagisawa, Isao,Isomura, Yasuo,Mase, Toshiyasu,Shibanuma, Tadao
, p. 3565 - 3571 (2007/10/03)
Isothiocyanates were treated with amino acetal and cone. HCl (0.5 eq.) successively in one-pot to afford 1-substituted imidazole-2-thiones in good yields.
