236739-03-0

Basic information

• Product Name: 1,4-Difluoro-2-(methylsulfonyl)benzene
• Synonyms: 2,5-DIFLUOROBENZYLMETHYLSULFON;1,4-Difluoro-2-(methylsulfonyl)benzene;1,4-Difluoro-2-(meth;2,5-Difluorophenyl methyl sulphone
• CAS NO: 236739-03-0
• Molecular Formula: C7H6F2O2S
• Molecular Weight: 192.18
• EINECS: 927-269-5
• Mol File: 236739-03-0.mol

Chemical Properties

• Boiling Point: 307.8 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: White to light yellow solid
• Density: 1.376 g/cm³
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: 1,4-Difluoro-2-(methylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Difluoro-2-(methylsulfonyl)benzene(236739-03-0)
• EPA Substance Registry System: 1,4-Difluoro-2-(methylsulfonyl)benzene(236739-03-0)

Safety Data

• Hazardous Substances Data: 236739-03-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Difluoro-2-(methylsulfonyl)benzene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of complex organic molecules that can be used in medicinal chemistry.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, 1,4-Difluoro-2-(methylsulfonyl)benzene is utilized as an intermediate in the production of agrochemicals, where its strong sulfone group can be incorporated into molecules with pesticidal or herbicidal properties.
Used in Material Science:
1,4-Difluoro-2-(methylsulfonyl)benzene is also used in material science for the development of new materials, leveraging its unique structural and chemical properties to create innovative compounds with specific applications.
Used as a Reagent in Organic Synthesis:
In organic synthesis, 1,4-Difluoro-2-(methylsulfonyl)benzene is employed as a reagent, facilitating various chemical reactions that lead to the formation of desired organic compounds.
Safety Note:
Given its potential hazardous nature, 1,4-Difluoro-2-(methylsulfonyl)benzene should be handled with care to prevent any adverse health effects, ensuring proper safety measures are in place during its use in research and industrial applications.

InChI:InChI=1/C7H6F2O2S/c1-12(10,11)7-4-5(8)2-3-6(7)9/h2-4H,1H3

Upstream product

• 540-36-3 para-difluorobenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 1101821-02-6 C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾ 
• 79-08-3 bromoacetic acid 

Relevant articles and documents

Asymmetric hydrogenation process

The present invention provides an asymmetric hydrogenation process for the preparation of chiral cycloalkanoindole DP receptor antagonists in high enantiomeric excess.

Methanesulfonylation of deactivated aromatics with superelectrophilic CH3so2F·3SbF5 and (CH3so2)2O-2CF3so 3H/B(O3SCF3)3 systems

Methanesulfonylation of various deactivated arenes, including tri- and tetrafluorobenzenes, was achieved in good yield under mild conditions using superelectrophilic CH3SO2F/3SbF5 and (CH3SO2O)2O/2CF3SO 3H-B(O3SCF3)3 reagent systems. 1998 MAHK "Hayka/Interperiodica".