23674-57-9Relevant academic research and scientific papers
Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides
Anderson, Alan J.,Nicholson, Jesse M.,Bakare, Oladapo,Butcher, Ray J.,Wilson, Tiffany L.,Scott
, p. 997 - 1006 (2006)
Structure-activity relationship studies were employed to synthesize a series of 3- and 3,4-substituted benzamides from 3-amino-2-cyclohexenones. An improved method for the synthesis of benzamides from 3-amino-2-cyclohexenones is presented which provided s
Kava analogues as agents for treatment of periodontal diseases: Synthesis and initial biological evaluation
Cai, Bin,Panek, James S.,Amar, Salomon
, p. 2667 - 2669 (2018)
Six kava analogues of the structural type 3-oxocyclohex-1-en-1-yl benzoates (and corresponding benzamides) were synthesized and evaluated for their affect on periodontal deconstruction in collagen anti-body primed oral gavage model of periodontitis. The c
Synthesis, characterization and anticonvulsant activity of enaminones. Part 6: Synthesis of substituted vinylic benzamides as potential anticonvulsants
Foster, James E.,Nicholson, Jesse M.,Butcher, Raymond,Stables, James P.,Edafiogho, Ivan O.,Goodwin, Angela M.,Henson, Michael C.,Smith, Carlynn A.,Scott
, p. 2415 - 2425 (2007/10/03)
A comparison of enaminones from various unsubstituted and p-substituted benzamides to the analogous benzylamines has been undertaken with the aim of elucidating the essential structural parameters necessary for anticonvulsant activity. Initial studies on methyl 4-N-(benzylamino)-6-methyl-2-oxocyclohex- 3-en-1-oate, 3a, 3-N-(benzylamino)cyclohex-2-en-1-one, 3p, and 5,5-dimethyl- 3-N-(benzylamino)-cyclohex-2-en-1-one, 3r indicated that benzylamines possessed significant anti-maximal electroshock seizure (MES) activity. Evaluation of the analogous benzamides revealed significant differences in anticonvulsant activity, these differences were most probably related to the differences in their three-dimensional structures. (C) 1999 Elsevier Science Ltd.
