236743-96-7Relevant articles and documents
Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides
Huwe, Christoph M.,Woltering, Thomas J.,Jiricek, Jan,Weitz-Schmidt, Gabriele,Wong, Chi-Huey
, p. 773 - 788 (2007/10/03)
Several aryl substituted C-fucopeptides have been developed as sialyl Lewis X mimetics. Although the compounds have a much simpler structure compared to SLe(x), up to 3-times higher binding affinity toward E-selectin and >1000 times toward P-selectin was observed. Furthermore, a convenient strategy for generating a number of analogues from a SLe(x) mimetic template at a very late stage of the synthesis was introduced, using a ruthenium catalyzed cross olefin metathesis under benchtop conditions. Copyright (C) 1999 Elsevier Science Ltd.