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Trabectedin intermediate is a chemical component integral to the synthesis of Trabectedin, a potent chemotherapy drug utilized in the treatment of advanced-stage soft tissue sarcoma. This intermediate ingredient is characterized by its cytotoxic properties, which are instrumental in disrupting the DNA repair mechanisms within cancer cells, thereby contributing to the therapeutic efficacy of the final drug formulation. The pharmaceutical industry highly values Trabectedin intermediate due to its significant role in cancer treatment, although the specific chemical composition and properties may differ based on the preparation process and methodology.

236743-98-9

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236743-98-9 Usage

Uses

Used in Pharmaceutical Industry:
Trabectedin intermediate is used as a key component in the manufacturing process for [application reason] its cytotoxic nature that aids in the disruption of DNA repair mechanisms in cancer cells, enhancing the therapeutic efficacy of Trabectedin in the treatment of advanced-stage soft tissue sarcoma. This intermediate is pivotal in the development of effective cancer-fighting drugs, making it an essential part of the pharmaceutical industry's efforts to combat this disease.

Check Digit Verification of cas no

The CAS Registry Mumber 236743-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,6,7,4 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 236743-98:
(8*2)+(7*3)+(6*6)+(5*7)+(4*4)+(3*3)+(2*9)+(1*8)=159
159 % 10 = 9
So 236743-98-9 is a valid CAS Registry Number.

236743-98-9Relevant academic research and scientific papers

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

Cuevas, Carmen,Perez, Marta,Martin, Maria J.,Chicharro, Jose L.,Fernandez-Rivas, Carolina,Flores, Maria,Francesch, Andres,Gallego, Pilar,Zarzuelo, Maria,De La Calle, Fernando,Garcia, Jesus,Polanco, Concepcion,Rodriguez, Ignacio,Manzanares, Ignacio

, p. 2545 - 2548 (2007/10/03)

(equation presented) An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).

Enantioselective synthesis of saframycin A and evaluation of antitumor activity relative to ecteinascidin/saframycin hybrids.

Martinez,Corey

, p. 75 - 77 (2008/02/11)

[formula: see text] A short synthesis of saframycin A is described which begins with a readily available intermediate previously utilized for the total synthesis of ecteinascidin 743. A key step in this synthesis is the use of 1-fluoro-3,5-dichloropyridin

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