236747-18-5Relevant academic research and scientific papers
Palladium-Catalyzed Direct Arylation of C(sp3)-H Bonds of α-Cyano Aliphatic Amides
Reddy, M. Damoder,Watkins, E. Blake
, p. 11447 - 11459 (2015)
Pd(OAc)2-catalyzed arylation of C(sp3)-H bonds in α-cyano-α-methyl aliphatic amides is achieved in the presence of 8-aminoquinoline, as a removable directing group, using Mn(OAc)2 and Na2CO3. The current strategy enables the placement of an aryl/heteroaryl group at the β-position of α-cyano aliphatic acids for the first time. Wide functional group tolerance and easily accessible starting materials provide an efficient protocol for the synthesis of arylated α-cyano amides. Furthermore, the synthetic utility of the products has been demonstrated by their efficient conversions to medicinally important α,α-dialkylated acid and β-amino acid derivatives.
Cobalt-catalyzed reductive carboxylation of α,β-unsaturated compounds with carbon dioxide
Hayashi, Chika,Hayashi, Takuo,Yamada, Tohru
, p. 862 - 870 (2015/06/25)
The gaseous carbon dioxide incorporation reaction with α,β-unsaturated compounds was examined in the presence of a catalytic amount of bis(acetylacetonato)cobalt(II) and using diethylzinc as a reductant. After screening with various electron-withdrawing g
Cobalt-catalyzed reductive carboxylation on α,β-unsaturated nitriles with carbon dioxide
Hayashi, Chika,Hayashi, Takuo,Kikuchi, Satoshi,Yamada, Tohru
supporting information, p. 565 - 567 (2014/04/17)
The reductive carboxylation of α,β-unsaturated carbonyl compounds with carbon dioxide was studied. After the screening of various transition-metal complex catalysts and reducing agents, it was found that the combination of bis(acetylacetonato) cobalt(II)
