23699-40-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-(2-Nitrophenoxy)phenyl)ethanone is used as a key intermediate in the synthesis of pharmaceuticals for [application reason]. Its unique structure allows for the creation of diverse drug candidates with potential therapeutic benefits.
Used in Dye and Pigment Production:
In the dye and pigment industry, 1-(4-(2-Nitrophenoxy)phenyl)ethanone is used as a starting material for the production of various dyes and pigments due to its distinctive color properties.
Used in Agrochemical Manufacturing:
1-(4-(2-Nitrophenoxy)phenyl)ethanone is utilized as a building block in the manufacturing of agrochemicals, where its chemical structure contributes to the development of effective compounds for agricultural applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-(2-Nitrophenoxy)phenyl)ethanone is used as a structural component in the development of new drugs and therapies. Its presence in the molecular structure can influence the pharmacological properties and potential therapeutic effects of the resulting compounds.

Upstream product

• 2216-12-8 1-nitro-2-phenoxy-benzene 
• 75-36-5 acetyl chloride 
• 1493-27-2 ortho-nitrofluorobenzene 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 23699-41-4 1-(4-(2-aminophenoxy)phenyl)ethan-1-one 
• 879096-38-5 2-[4-[1-methoxyiminoethyl]phenoxy]nitrobenzene 
• 108011-32-1 2-bromo-1-[4-(2-nitro-phenoxy)-phenyl]-ethanone 

Relevant academic research and scientific papers

A homologous enolate Truce-Smiles rearrangement

During preparation of a series of diphenyl ethers it was observed that displacement of an activated aryl fluoride with ortho-hydroxyacetophenone afforded a product that was C-arylated adjacent to the ketone. Evidence suggested this product was formed by Smiles rearrangement of an O-arylated intermediate.

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop

Microtubule targeting agents represent a very active arena in the development of anticancer agents. In particular, compounds binding at the colchicine site in tubulin are being deeply studied, and the structural information recently available on this binding site allows structure-directed design of new ligands. Structural comparison of our recently reported high resolution X-Ray structure of the cyclohexanedione derivative TUB075 bound to tubulin and the tubulin-DAMA-colchicine complex has revealed a conformational change in the αT5 loop. By a grid-based computational analysis of the tubulin-DAMA-colchicine binding site, we have identified a new favourable binding area in the colchicine-site that was unexplored by our lead TUB075. Thus, based on a structure-guided design, new cyclohexanedione derivatives have been synthesized and tested for tubulin binding and in cellular assays. As a result, we have identified diphenyl ether derivatives with IC50 values around 10–40 nM against three different tumor cell lines and affinity constants for tubulin similar to that of colchicine around 107 M?1. As expected, they halted the cell cycle progression at G2/M phase at concentrations as low as 0.08 μM.

(HETERO)CYCLYL(THIO) CARBOXYLIC ACID ANILIDES FOR CONTROLLING PATHOGENIC FUNGI

The invention relates to (hetero)cyclyl(thio)carboxylic acid anilides of general formula (I) and to salts of said anilides that can be used for agricultural purposes for controlling pathogenic fungi. In said formula, the variables are defined as follows: A represents a phenyl or at least a monounsaturated 5- or 6-membered heterocycle comprising 1, 2 or 3 heteroatoms, selected from N, O, S, S(=O) and S(=O)2 as ring members, whereby phenyl and the monounsaturated 5- or 6-membered heterocycle can be unsubstituted or can be substituted according to the description; B represents a group of general formula (II), in which the variables R3, R4, R5 and the index m are defined as cited in the claims and the description; Y represents oxygen or sulphur, R1 represents H, OH, alkyl, cycloalkyl, alkoxy, haloalkyl, halocycloalkyl or haloalkoxy; R2 represents halogen, nitro, CN, alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, haloalkyl, halocycloalkyl, haloalkenyl, haloalkynyl or haloalkoxy; and n represents 0, 1, 2, 3 or 4; and salts that can be used for agricultural purposes. The invention also relates to the use of the (hetero)cyclyl(thio)carboxylic acid anilides of general formula (I), to a method for controlling pathogenic fungi and to a crop protection agent containing at least one compound of general formula (I) and/or an agriculturally compatible salt of said compound.

Neutral alumina-K2CO3: An eco-friendly system for synthesis of diaryl ethers under microwave irradiation

Electron deficient halo benzenes undergo smoothly direct condensation with a wide range of phenols under microwave irradiation using neutral alumina as solid support to yield biaryl ethers in excellent yields.

2-Phenoxyaniline derivatives

PCT No. PCT/JP98/04729 Sec. 371 Date Apr. 10, 2000 Sec. 102(e) Date Apr. 10, 2000 PCT Filed Oct. 20, 1998 PCT Pub. No. WO99/20598 PCT Pub. Date Apr. 29, 1999A 2-phenoxyaniline derivative represented by the formula: wherein R1 is a hydrogen atom or a lower alkoxy group, R2 is a halogen atom or a nitro group, and R3 is a hydrogen atom or a halogen atom, or a pharmaceutically acceptable salt thereof.