2371-25-7

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 87-62-7 2,6-dimethylaniline 
• 105-36-2 ethyl bromoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 103095-36-9 2,6-dimethylanilino-acetic acid 
• 87544-28-3 [3-Benzoyl-1-(2,6-dimethyl-phenyl)-thioureido]-acetic acid ethyl ester 
• 87544-31-8 [1-(2,6-Dimethyl-phenyl)-3-(4-methoxy-benzoyl)-thioureido]-acetic acid ethyl ester 
• 87544-40-9 1-(2,6-Dimethyl-phenyl)-2-thioxo-imidazolidin-4-one 
• 87544-38-5 3-(2,6-Dimethyl-phenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid 
• 87544-41-0 3-Benzoyl-1-(2,6-dimethyl-phenyl)-2-thioxo-imidazolidin-4-one 
• 87544-46-5 3-(2,6-Dimethyl-phenyl)-5-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid 
• 87544-39-6 3-(2,6-Dimethyl-phenyl)-5-phenyl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester 
• 87544-48-7 N-[3-(2,6-Dimethyl-phenyl)-5-oxo-thiazolidin-(2Z)-ylidene]-4-methoxy-benzamide 
• 87544-47-6 3-(2,6-Dimethyl-phenyl)-5-(4-methoxy-phenyl)-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester 
• 104412-24-0 C₁₀H₁₂N₂O₃ 
• 104411-97-4 3-(2,6-dimethylphenyl)sydnone 
• 2370-48-1 2-[(2,6-dimethylphenyl)amino]acetohydrazide 

Relevant academic research and scientific papers

Synthesis, cytotoxic evaluation, and molecular docking studies of new oxadiazole analogues

Background: Cancer is one of the major health diseases worldwide with an approximately 14 million new cases of cancer and 8.2 million cancer related death tolls were reported in 2012. The major complications associated with chemotherapy are limited effica

Selective carbene transfer to amines and olefins catalyzed by ruthenium phthalocyanine complexes with donor substituents

Electron-rich ruthenium phthalocyanine complexes were evaluated in carbene transfer reactions from ethyl diazoacetate (EDA) to aromatic and aliphatic olefins as well as to a wide range of aromatic, heterocyclic and aliphatic amines for the first time. It was revealed that the ruthenium octabutoxyphthalocyanine carbonyl complex [(BuO)8Pc]Ru(CO) is the most efficient catalyst converting electron-rich and electron-poor aromatic olefins to cyclopropane derivatives with high yields (typically 80-100%) and high TON (up to 1000) under low catalyst loading and nearly equimolar substrate/EDA ratio. This catalyst shows a rare efficiency in the carbene insertion into amine N-H bonds. Using a 0.05 mol% catalyst loading, a high amine concentration (1 M) and 1.1 eq. of EDA, a number of structurally divergent amines were selectively converted to mono-substituted glycine derivatives with up to quantitative yields and turnover numbers reaching 2000. High selectivity, large substrate scope, low catalyst loading and practical reaction conditions place [(BuO)8Pc]Ru(CO) among the most efficient catalysts for the carbene insertion into amines.

Synthesis and bioactivity of novel (Z,E)-1-(substituted phenyl)-3-[α -(alkyloxyimino)benzylidene]pyrrolidine-2,4-dione derivatives

A series of 1-(substituted phenyl)-3-[α-(alkyloxyimino)-benzylidene] pyrrolidine-2,4-dione derivatives as a mixture of two geometrical isomers of Z-configuration and E-configu-ration were synthesized by the reaction of the corresponding α -hydroxybenzylidene analogs with alkyloxyamine hydro-chlorides. The target compounds were confirmed by IR, 1 H NMR, MS and elemental analysis. The title compounds exhibit inhibitory activity against Echinochloa crusgalli and Brassica campestris. Copyright by Walter de Gruyter Berlin Boston.

Bromination of Sydnones. I. Reaction with 3-Arylsydnones Containing Electron-Donors on the Aryl Ring

Bromination has been examined for a series of 3-arylsydnones (1) with electron donors (dimethyl to dimethoxy) on the aryl ring.In no example was exclusive aryl ring bromination observed, however, exclusive sydnone ring bromination could be realized in every case.For two dimethoxyphenyl examples both aryl and sydnone ring bromination occurred.

Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives

The synthesis of N-(3-mercaptopropionyl)-N-arylglycines (14a-x), -N-arylalanines (15a,b), -N-cycloalkylglycines (16a-k), and -1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids (17a-d), -1,2,3,4-tetrahydroquinoline-2-carboxylic acids (18a-f), and -indoline-2-carboxylic acids (19a-k) is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound, and the structure-activity relationship for each series is discussed. The in vivo inhibition of ACE and antihypertensive effects of representative compounds from each series are discussed. The most potent compound, 19d, had an in vitro ACE IC50 of 2.6 x 10-9 M and lowered blood pressure in spontaneous hypertensive rats 85 mm at a dose of 10 mg/kg po.