23711-34-4

Basic information

• Product Name: 5-(2-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol
• Synonyms: 3H-1,2,4-triazole-3-thione, 5-(2-chlorophenyl)-2,4-dihydro-4-phenyl-; 4H-1,2,4-Triazole-3-thiol, 5-(2-chlorophenyl)-4-phenyl-; 5-(2-Chlorophenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione; 5-(2-Chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol
• CAS NO: 23711-34-4
• Molecular Formula: C₁₄H₁₀ClN₃S
• Molecular Weight: 287.7673
• Mol File: 23711-34-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 398.8°C at 760 mmHg
• Flash Point: 195°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.44E-06mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 5-(2-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol(23711-34-4)
• EPA Substance Registry System: 5-(2-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiol(23711-34-4)

Safety Data

• Hazardous Substances Data: 23711-34-4(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 5814-05-1 2-chlorobenzoylhydrazide 
• 26036-04-4 1-(o-chlorobenzoyl)-4-phenyl-3-thiosemicarbazide 

Downstream Products

• 81518-32-3 3-(2-Chloro-phenyl)-4-phenyl-5-propylsulfanyl-4H-[1,2,4]triazole 
• 81518-30-1 3-(2-Chloro-phenyl)-5-ethylsulfanyl-4-phenyl-4H-[1,2,4]triazole 
• 81518-31-2 3-Allylsulfanyl-5-(2-chloro-phenyl)-4-phenyl-4H-[1,2,4]triazole 
• 81518-29-8 3-(2-Chloro-phenyl)-5-methylsulfanyl-4-phenyl-4H-[1,2,4]triazole 

Relevant articles and documents

Synthesis and biological evaluation of 1, 2, 4-triazoles and 1, 3, 4-oxadiazoles derivatives linked to 1, 4-dihydropyridines scaffold

A series of diethyl-2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-dicarboxylate derivative coupled to 1, 3, 4-oxadiazole-5-thiones and 1, 2, 4-triazole-5-thiones moieties at C2, C6 positions of 1, 4-dihydropyridine ring system was prepared. This linkage was carried out by the reaction of 1, 3, 4-oxadiazole-5-thiones and 1, 2, 4-triazole-5-thiones with 2, 6-dibromomethyl-3, 5-diethoxycarbonyl-4-phenyl-1, 4-dihydropyridine in the presence of potassium carbonate as a weak base and dry acetone as the solvent. The newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and FAB-MS. The synthesized compounds were tested for their antimicrobial and antifungal activity against Escherichia coli and Aspergillus fumigatus in vitro in comparison with Enrofloxacin and Amphotericin as the reference drugs which are normally used for treating such infections. The synthetic compounds showed different inhibition zones against tested bacteria and fungi. Compound 8d showed more antagonistic activity against E. coli and A. fumigatus.