26036-04-4

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 5814-05-1 2-chlorobenzoylhydrazide 

Downstream Products

• 153260-29-8 N-(3-phenyl-2-thioxo-2,5-dihydro-4,6-pyrimidinedionyl)-2-chlorobenzoic acid amide 
• 23711-34-4 5-(2-chloro-phenyl)-4-phenyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 153260-30-1 N-<3-phenyl-2-thioxo-2,5-dihydro-3-(2-chlorophenylcarboxamido)-4,6-pyrimidinedionyl>propionic acid 
• 153260-35-6 N-<3-phenyl-2-thioxo-2,5-dihydro-3-(2-chlorophenylcarboxamido)-5-anilinomethyl-4,6-pyrimidinedionyl>propionic acid 
• 1355947-41-9 1,2,4,5-tetrakis[5-(2-chlorophenyl)-4-phenyl-1,2,4-triazol-3-ylthiomethyl]benzene 
• 23766-12-3 [5-(2-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-phenyl-amine 
• 135815-41-7 Pd(C₆H₅NHCSNHNHCOC₆H₄-o-Cl)Cl₂ 
• 81518-32-3 3-(2-Chloro-phenyl)-4-phenyl-5-propylsulfanyl-4H-[1,2,4]triazole 
• 81518-30-1 3-(2-Chloro-phenyl)-5-ethylsulfanyl-4-phenyl-4H-[1,2,4]triazole 
• 81518-31-2 3-Allylsulfanyl-5-(2-chloro-phenyl)-4-phenyl-4H-[1,2,4]triazole 
• 81518-29-8 3-(2-Chloro-phenyl)-5-methylsulfanyl-4-phenyl-4H-[1,2,4]triazole 

Relevant academic research and scientific papers

Synthesis of 1,2,4,5-tetrakis(1,2,4-triazolyl) benzene and 1,2,4,5-tetrakis(1,3,4-oxadiazolyl) benzene derivatives

A series of 1,2,4,5-tetrakis(1,2,4-triazolyl)benzenes and 1,2,4,5-tetrakis(1,3,4-oxadiazolyl)benzenes was synthesized by nucleophilic addition of sodium salts of 4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 1,3,4-oxadiazole-2(3H)-thiones to 1,2,4,5-tetrakis(bromomethyl)benzene. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR and 1H and 13C NMR spectra. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: 1H and 13C NMR spectra of products (Figures S1-S24).

Synthesis and biological evaluation of 1, 2, 4-triazoles and 1, 3, 4-oxadiazoles derivatives linked to 1, 4-dihydropyridines scaffold

A series of diethyl-2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-dicarboxylate derivative coupled to 1, 3, 4-oxadiazole-5-thiones and 1, 2, 4-triazole-5-thiones moieties at C2, C6 positions of 1, 4-dihydropyridine ring system was prepared. This linkage was carried out by the reaction of 1, 3, 4-oxadiazole-5-thiones and 1, 2, 4-triazole-5-thiones with 2, 6-dibromomethyl-3, 5-diethoxycarbonyl-4-phenyl-1, 4-dihydropyridine in the presence of potassium carbonate as a weak base and dry acetone as the solvent. The newly synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and FAB-MS. The synthesized compounds were tested for their antimicrobial and antifungal activity against Escherichia coli and Aspergillus fumigatus in vitro in comparison with Enrofloxacin and Amphotericin as the reference drugs which are normally used for treating such infections. The synthetic compounds showed different inhibition zones against tested bacteria and fungi. Compound 8d showed more antagonistic activity against E. coli and A. fumigatus.

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione with 5,11,17,23-tetra-tert-butyl-25,27-bis(3-bromopropoxy)-26,28-dihydroxycalix[4]arene (2). The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and ESI-MS.

Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles

A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol

Anion binding of N-(o-Methoxybenzamido)thioureas: Contribution of the intramolecular hydrogen bond in the N-benzamide moiety

N-(o-Methoxybenzamido)- thioureas (2X/2Y) are found to show an enhanced anion binding affinity with binding constants over 107 mol -1L orders of magnitude for AcO- and a redshifted absorption of the anion binding complexes in acetonitrile (MeCN) relative to those of N-benzamidothioureas (1) that bear no o- OMe in the N-benzamide moiety, despite the electron-donating character of o-OMe. Absorption of the anion-2X/ 2Y complex was shown to be of the same charge-transfer nature as that of the anion-1 complex, but its dependence on substituent X is interestingly influenced by the o-MeO···HNC=O six-membered-ring intramolecular hydrogen bond identified in 2X/2Y. Such an intramolecular hydrogen bond is suggested to be responsible for the enhanced anion binding affinity. In the presence of this intramolecular hydrogen bond, the anion binding constant of 2X was found to be independent of substituent X at the N-phenyl ring, as in the case of 1, whereas that of 2Y showed an amplified dependence on substituent Y at the N′-phenyl ring, but to a lower extent than that of 1. A similar ring intramolecular hydrogen bond was purported to exist in 2Za, 2Zd, and 2Ze, which bear NHMe, F, and Cl as the ortho substituent in the N-benzamide moiety. In terms of the current roles of thiourea in not only anion recognition and sensing but also organocatalysis and crystal engineering, the present finding would be of significance for a wider structural diversity of smart thiourea derivatives with predesigned functions.

Novel thioxopyrimidinedione derivatives: anti-inflammatory and analgesic agents

Some novel thioxopyrimidinedione derivatives have been synthesised and their anti-inflammatory activity in albino rats evaluated.Two compounds (3, 5a) showing potent activity were further studied at graded doses for their ED50 values.The LD50 values of th

Synthesis and characterization of palladium(II) complexes derived from aromatic thiosemicarbazide derivatives

The reaction of aromatic thiosemicarbazides with palladium(II) ions give three type of complexes having the composition PdLCl2, Pd(L-H)2 and Pd(L-2H) .Elemental analyses, molar conductivities, magnetic measurements and spe

Efficiency of Some Phenylthiosemicarbazide Derivatives in Retarding the Dissolution of Al in NaOH Solution

Five derivatives of phenylthiosemicarbazide have been prepared and treated as inhibitors for the corrosion of aluminium in 2 M sodium hydroxide.All the five substances afford 98,5 to 75percent protection to aluminium in sodium hydroxide. 1-(Methoxybenzoyl