23722-52-3

Upstream product

• 162251-00-5 3-(3,4-Dichloro-phenyl)-3-oxo-propionaldehyde 
• 186581-53-3 diazomethane 
• 3024-72-4 3,4-dichlorobenzoyl chloride 
• 2642-63-9 3',4'-dichloroacetophenone 
• 51-44-5 3,4-dichlorbenzoic acid 

Downstream Products

• 5807-30-7 3,4-dichlorophenyl acetic acid 
• 1285704-80-4 (E)-4-ethyl 1-methyl 2-(4-methoxyphenyl)fumarate 
• 132545-38-1 (E)-4-ethyl 1-methyl 2-phenylfumarate 
• 1520-50-9 but-2-enedioic acid diethyl ester 
• 1285705-13-6 (E)-methyl 4-(3,4-dichlorophenyl)-4-oxo-2-phenylbut-2-enoate 
• 6831-55-6 2-(3,4-dichlorophenyl)acetyl chloride 

Relevant academic research and scientific papers

Rhodium(II)-catalyzed cross-coupling of diazo compounds

Nothing left to chance: A convenient protocol for selective cross-coupling of diazo compounds for the convergent synthesis of alkenes was developed (see scheme; EDG=aryl, heteroaryl, vinyl; R=O-alkyl, aryl). The selectivity control elements were identifie

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

40. Diazoaldehyde chemistry: Part 3. Synthesis of 4-acyl-1H-1,2,3-triazole derivatives

Ten new α -diazo-β-oxoaldehydes were condensed with aniline, ammonia, hydroxylamine, and semicarbazide to yield new 4-acyl-(1-substituted)-1H-1,2,3-triazoles in moderate-to-good yields. The method is simple and regiospecific. The latter feature makes this method superior to the widely used acylacetylene + azide approach.

Diazoaldehyde Chemistry. Part 1. Transdiazotization of Acylacetaldehydes in Neutral-to-Acidic Medium. A Direct Approach to the Synthesis of α-Diazo-β-oxoaldehydes

First ever non-deformylating transdiazotization of acylacetaldehydes was achieved: the reactions of 2-azido-1-ethylpyridinium tetrafluoroborate (4) with acylacetaldehydes 3 proceeded partially without deformylation to yield 16 new α-diazo-β-oxoaldehydes 1 along with diazomethyl ketones 2, especially in the presence of NaOAc (Scheme 1, Tables 1 and 2).The product distribution was substituent-dependent and could be correlated quantitatively.This new diazotization reaction appears as an alternative, direct, and more general method for the synthesis of these diazooxoaldehydes. α-Oxocycloalkanecarbaldehydes 5 gave only traces (if any) of α-diazocycloalkanones 7, and rearrangement products 6 were isolated (Scheme 2).Mechanisms of the reactions are discussed (Schemes 4 and 5).