23724-60-9

Usage

Uses

Used in Infrared Spectral Studies:
ACETAMIDE-2,2,2-D3 is used as a reference compound for infrared spectral studies, providing valuable information on the normal vibrations of acetamide and its deuterated analogs. The deuterium substitution alters the vibrational frequencies, making it easier to analyze and differentiate between various molecular structures.
Used in Normal Vibrations Analysis:
In the field of molecular vibrations, ACETAMIDE-2,2,2-D3 serves as a useful tool for analyzing the normal vibrations of acetamide and its deuterated analogs. The presence of deuterium atoms in the compound leads to distinct vibrational patterns, which can be utilized to study the molecular dynamics and interactions of these compounds.

Upstream product

• 53778-70-4 trideuteroacetic acid isopropyl ester 
• 1112-02-3 d⁽³⁾-acetic acid 
• 2206-26-0 [D₃]acetonitrile 
• 1186-52-3 tetradeuterioacetic acid 

Downstream Products

• 16727-10-9 Perdeutero-N,N-dimethyl-acetamid 
• 114533-13-0 N-benzyl-[C-²H₃]acetamide 

Relevant academic research and scientific papers

A low temperature matrix isolation infrared study of acetamides. I. Acetamide and some deuterated derivatives

The IR spectra of acetamide and some of its deuterated derivatives in argon matrices (14 K) have been obtained in the region 4000-200 cm-1.An injection system was developed to avoid multiple site splitting.A normal coordinate analysis has been carried out for the a" vibrational modes and from the C NH2 torsional force constant the potential barrier was calculated to be 81 kJ mol-1.

DEUTERATED FEZOLINETANT

The present invention relates to deuterated fezolinetant (R)-(4-fluorophenyl)-(8-methyl-3-(3-(methyl-d3)-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]trizolo[4,3-a]pyrazin-7(8H)-yl)methanone, or a pharmaceutically acceptable solvate thereof, as NK-3 antagoni

Transamidation of primary amides with amines catalyzed by zirconocene dichloride

Zirconocene dichloride (Cp2ZrCl2) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80°C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30°C.

Transamidation of primary amides with amines catalyzed by zirconocene dichloride

Zirconocene dichloride (Cp2ZrCl2) has been shown to be an effective catalyst for the transamidation of primary amides with amines in cyclohexane at 80°C in 5-24 hours. For favourable substrates, the reaction can be performed at temperatures as low as 30°C.

Synthesis of the perdeuterated cellulose solvents N-methylmorpholine N-oxide (NMMO-d11) and N,N-dimethylacetamide (DMAC-d9)

The synthesis of the perdeuterated cellulose solvents NMMO-d11 (9) and N,N-dimethylacetamide-d9 (14) is described. NMMO-d 11 was obtained according to a five-step approach from non-labeled diglycolic acid (1) via diethylene glycole-d8 (4) and its bis-tosylate (5), which underwent cyclization with benzylamine to N-benzylmorpholine (6). The removal of the benzyl protecting group, methylation and N-oxidation completed the synthesis. DMAc-d9 (14) was obtained from deuterated acetic acid (10) and dimethylamine-carbon dioxide complex (17) with acidic alumina as the catalyst according to a solvent-free gas-solid reaction. Copyright