23724-93-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Methoxyisoquinoline is used as a precursor for the synthesis of other important chemical compounds and pharmaceuticals, due to its versatile chemical structure and potential to be modified for specific therapeutic applications.
Used in Antimicrobial Applications:
1-Methoxyisoquinoline is utilized as an antimicrobial agent for its ability to combat various microorganisms, which can be beneficial in the development of new antibiotics or disinfectants.
Used in Antioxidant Applications:
As an antioxidant, 1-Methoxyisoquinoline is employed to neutralize free radicals, potentially protecting cells from oxidative damage and contributing to the development of treatments for conditions associated with oxidative stress.
Used in Anti-Inflammatory Applications:
1-Methoxyisoquinoline is used as an anti-inflammatory agent, leveraging its capacity to reduce inflammation, which can be instrumental in the management of inflammatory diseases.
Used in Alzheimer's Disease Treatment Research:
1-Methoxyisoquinoline is studied for its potential use in the treatment of Alzheimer's disease, possibly due to its neuroprotective properties or its ability to target specific pathological mechanisms associated with the condition.
Used in Cancer Treatment Research:
1-Methoxyisoquinoline is explored for its potential role in cancer treatment, with research focusing on its ability to target cancer cells, inhibit tumor growth, or enhance the effectiveness of existing cancer therapies.

InChI:InChI=1/C10H9NO/c1-12-10-9-5-3-2-4-8(9)6-7-11-10/h2-7H,1H3

Upstream product

• 55417-70-4 1-chloro isoquinoline N-oxide 
• 19493-44-8 1-chloroisoquinoline 
• 115483-66-4 2-(2,2-Diethoxyethylthio)benzamid 
• 115483-67-5 1,4-Benzothiazepin-5(4H)-on 
• 2527-57-3 2,2'-dithiobisbenzamide 
• 74-88-4 methyl iodide 
• 115483-69-7 5-Methoxy-1,4-benzothiazepin 
• 76570-09-7 1-methoxyisoquinoline 2-oxide 
• 124-41-4 sodium methylate 
• 491-30-5 1-hydroxyisoquinoline 

Downstream Products

• 16576-23-1 1-benzoylisoquinoline 
• 4594-71-2 N-methylisocarbostyril 
• 27302-13-2 α-phenyl-1-isoquinolineacetonitrile 

Relevant academic research and scientific papers

Organic Superbase t-Bu-P4 Catalyzes Amination of Methoxy(hetero)arenes

We report that the organic superbase t-Bu-P4 efficiently catalyzes the amination of methoxy(hetero)arenes with amine nucleophiles such as aniline, indoline, and aminopyridine derivatives. This catalytic reaction is effective for the transformation of elec

On the thermally induced rearrangement of 2-alkoxypyridines to N-alkylpyridones

Analogues of 2-methoxypyridine undergo rearrangement to N-methylpyridones under flash vacuum pyrolysis (FVP) conditions. Ethoxy derivatives undergo competitive ethyl migration and elimination of ethylene. Analogues of 4-methoxypyridine do not undergo rearrangement under FVP conditions, but demethylation on silica may occur. The ease of rearrangement follows the basicity of the alkoxyhetarene to some extent. The vapour-phase rearrangements have been contrasted to condensed-phase pyrolyses. and a four-centre transition state for the former is supported by computation. The rearrangement allows structural assignment to the two products from the reaction of 2,4-dichloroquinoline with pyrrolidine.

Heterocyclic Seven-Membered Ring Compounds, XXXIII. - Synthesis and Properties of 5-Methoxy-1,4-benzothiazepine and of 5-Methoxy-1-methyl-1,4-benzothiazepinium Tetrafluoroborate

Acid-catalyzed cyclisation of the amide acetal 2 yields the seven-membered ring lactam 3 which could be N-methylated to give compound 4 by treatment with sodium hydride/methyl iodide.On reaction with trimethyloxonium tetrafluoroborate, 3 was O-alkylated to yield the title thiazepine 5, the thermal stability of which is compared with that of the isomeric 4-methoxy-1,5-benzothiazepine C.Compound 5 could be oxidized to give the sulfone 6; thermolysis of 5 leads to sulfur and 1-methoxyisoquinoline (8).Alkylation of 5 with methyl iodide/silver tetrafluoroborate yields the sulfonium salt 7 which rearranges to 1-methoxy-4-(methylthio)isoquinoline (9) on heating in acetonitrile.

Photochemistry of Methoxy-substituted Quinoline and Isoquinoline N-Oxides

The photochemistry of quinoline 1-oxides and isoquinoline 2-oxides bearing a methoxy-group in the pyridine ring was investigated in protic and aprotic media.The formation of various photoisomers, viz. 3,1-benzoxazepines, 2(1H)-quinolones, N-(2-isocyanobenzyl)formamides, 4(1H)-quinolones, and 3-hydroxyquinolines from the different methoxyquinoline 1-oxides, and 1,3-benzoxazepines and 1(2H)-isoquinolones from the different methoxyisoquinoline 2-oxides, was observed along with deoxygenation and formation of products derived from hydration and decomposition of the primary products.The position of the methoxy-group has an important directing effect on the photoreactions.