23729-96-6Relevant academic research and scientific papers
Sulfonimidamide analogs of oncolytic sulfonylureas
Toth, John E.,Grindey, Gerald B.,Ehlhardt, William J.,Ray, James E.,Boder, George B.,Bewley, Jesse R.,Klingerman, Kim K.,Gates, Susan B.,Rinzel, Sharon M.,Schultz, Richard M.,Weir, Leonard C.,Worzalla, John F.
, p. 1018 - 1025 (2007/10/03)
A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma, and (3) metabolic breakdown to the o-sulfate of p- chloroaniline. The separated enantiomers of one sulfonimidamide analog displayed very different activities in the in vivo screening model. In general, several analogs demonstrated excellent growth inhibitory activity in the 6C3HED model when dosed orally or intraperitoneally. A correlative structure-activity relationship to the oncolytic sulfonylureas was not apparent.
Nitrosations with hydrazine derivatives: Synthesis of N4-arenesulfinylsemicarbazides and N5-arenesulfinyl-N1-aminobiuretes from arenesulfinylisocyanates and N,N-disubstituted hydrazines
Hanefeld,Landwehr
, p. 344 - 351 (2007/10/02)
Arenesulfinyl-isocyanates 5 prepared in situ from arenesulfinyl chlorides 4 and silver cyanate react with N,N-disubstituted hydrazines to mixtures of N4-arenesulfinylsemicarbazides 6 as main components and N5-arenesulfinyl-N1/s
