2373-31-1Relevant articles and documents
N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of 6-alkoxy-2-oxo-2H-chromene-4-carbaldehydes: synthesis, evaluation of their antibacterial, anti-MRSA, antifungal activity, and docking study
Toan, Vu Ngoc,Thanh, Nguyen Dinh,Khuyen, Vu Hong,Tu, Luu Thi Cam,Tri, Nguyen Minh,Huong, Nguyen Thi Thu
, p. 743 - 759 (2021)
Reaction of 6-alkoxy-2-oxo-2H-chromen-4-carbaldehydes with N-(2,3,4,6-tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazide yielded corresponding thiosemicarbazones having 2H-chromen-2-one ring. In vitro evaluations showed that these 2H-chromen-2-one compounds exhibited remarkable antibacterial and antifungal activities against some typical bacteria and fungi. Representative compounds with MIC values of 0.78 ? 1.56 μg/mL were 6c, 6g (against S. aureus), 6a, 6f (against S. epidermidis) (Gram-positive bacterial strains), 6e, 6g (against E. coli), 6b, 6e (against K. pneumoniae), and 6d–f (against S. typhimurium) (Gram-negative bacterial strains). Almost all thiosemicarbazones 6a–g had no activity against Gram-positive bacterial strain B. subtilis at these MIC values. Some compounds had strong inhibitory activity against several bacteria, such as 6b (for K. pneumoniae and S. typhimurium), 6d, 6e (for E. coli, K. pneumoniae, and S. typhimurium), 6f (for S. aureus, E. coli, and S. typhimurium), and 6g (for B. subtilis, S. aureus, E. coli, and K. pneumoniae). Some compounds had remarkable inhibitory activity against three clinical MRSA isolates with MIC values of 0.78–6.25 μg/mL. Docking study showed that compound 6g is compatible with the active site of S. aureus DNA gyrase 2XCT, which suggested that the tested compounds inhibited the synthesis of this enzyme. [Figure not available: see fulltext.]
A highly selective chemosensor for naked-eye sensing of nanomolar Cu(II) in an aqueous medium
Qian, Yaao,Cao, Li,Jia, Chunman,Boamah, Peter Osei,Yang, Qiuyun,Liu, Chunling,Huang, Yan,Zhang, Qi
, p. 77965 - 77972 (2015)
A novel highly selective and sensitive colorimetric chemosensor L for the detection of Cu2+ ion with a fast response time was designed and synthesized. Receptor L detected Cu2+ ion by changing its color from colorless to magenta in a semi-aqueous solution. The limit of detection for Cu2+ was calculated to be as low as 28 nM. The possible binding mode of compound L with Cu2+ ion was studied using the Job's method, HRMS, FTIR spectroscopy and 1H NMR spectroscopy titration. Importantly, test strips containing L were fabricated as a naked-eye indicator for Cu2+ ion in pure water samples.
Synthesis and antiproliferative activity of 6,7-aryl/hetaryl coumarins
Jayaprakash Rao,Yadaiah Goud,Hemasri,Jain, Nishant,Gabriella, Srujana
, p. 184 - 189 (2016)
Two different series of novel analogs of 6,7-aryl/hetaryl coumarins 4a-4h and 8i-8l have been synthesized by using Suzuki-Miyara cross coupling reaction from 4-methyl-2-oxo-2H-chromen-7-yl trifluoro-methanesulfonate and 4-methyl-2-oxo-2H-chromen-6-yl trifluoromethanesulfonate in high yields (70-90%). All synthesized compounds were elucidated by means of IR, 1H NMR, 13C NMR, and MS spectra. The synthesized compounds were tested for antiproliferative activity against different human cancer cell lines (SiHa, MDAMB-231, and PANC-1) and some of products demonstrated the distinctive effect.
A Reusable Column Method Using Glycopolymer-Functionalized Resins for Capture–Detection of Proteins and Escherichia coli
Ajish, Juby K.,Abraham, Hephziba Maria,Subramanian, Mahesh,Kumar, K. S. Ajish
, (2020/12/21)
The use of glycopolymer-functionalized resins (Resin–Glc), as a solid support, in?column mode for bacterial/protein capture and quantification is explored. The Resin–Glc is synthesized?from commercially available chloromethylated polystyrene?resin and glycopolymer, and is characterized by fourier transform infrared spectroscopy, thermogravimetry, and elemental analysis. The percentage of glycopolymer functionalized on Resin–Glc is accounted to be 5 wt%. The ability of Resin–Glc to selectively capture lectin, Concanavalin A, over Peanut Agglutinin, reversibly, is demonstrated for six cycles of experiments. The bacterial sequestration study using SYBR (Synergy Brands, Inc.) Green I tagged?Escherichia coli/Staphylococcus aureus?reveals the ability of Resin–Glc to selectively capture?E. coli?over?S. aureus. The quantification of captured cells in the column is carried out by enzymatic colorimetric assay using methylumbelliferyl glucuronide?as the substrate. The?E. coli?capture studies reveal a consistent capture efficiency of 105?CFU (Colony Forming Units) g?1 over six cycles. Studies with spiked tap water samples show satisfactory results for?E. coli?cell densities ranging from 102 to 107?CFU mL?1. The method portrayed can serve as a basis for the development of a reusable solid support in capture and detection of proteins and bacteria.
