237419-31-7Relevant academic research and scientific papers
Asymmetric synthesis and pharmacology of methylphenidate and its para- substituted derivatives
Thai, Dung L.,Sapko, Michael T.,Reiter, Clara T.,Bierer, Donald E.,Perel, James M.
, p. 591 - 601 (2007/10/03)
We report the first asymmetric synthesis of the individual enantiomers of methylphenidate (1). From d-pipecolic acid, the (2R,2'R) and (2S,2'R) enantiomers of 1 were obtained in >99% optical purity while the (2S,2'S) and (2R,2'S) enantiomers of 1 were der
