237429-65-1

Usage

Benzimidazole derivative

A compound based on the benzimidazole structure This refers to the core structure of the molecule, which is a benzimidazole ring. Benzimidazoles are known for their diverse biological activities and potential applications in medicinal chemistry.

Carbonitrile functional group

A cyano group (C≡N) attached to the benzimidazole ring This functional group is responsible for some of the compound's chemical reactivity and potential applications.

Aminoethyl side chain

An ethylamine group (NH2-CH2-CH3) attached to the benzimidazole ring This side chain contributes to the compound's potential as a precursor for the synthesis of other bioactive compounds.

Potential applications in medicinal chemistry

The compound's diverse biological activities, such as antiparasitic, antibacterial, antiviral, and anticancer properties These activities make 1H-Benzimidazole-5-carbonitrile, 2-(2-aminoethyl)-(9CI) a promising candidate for the development of new drugs and therapies.

Interest to researchers in the pharmaceutical and chemical industries

Due to its unique structure and potential biological activities This highlights the importance of studying 1H-Benzimidazole-5-carbonitrile, 2-(2-aminoethyl)-(9CI) for the development of new compounds and applications in various industries.

Upstream product

• 17626-40-3 4-cyano-1,2-phenylenediamine 
• 107-95-9 3-amino propanoic acid 

Downstream Products

• 237429-50-4 N-[2-(5-phenyl-1H,3'H,3''H-[2,5';2',5'']terbenzoimidazol-2''-yl)-ethyl]-acetamide 

Relevant academic research and scientific papers

2'-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. No cross-resistance was observed for 1 when it was evaluated against the camptothecin-resistant cell line, CPT-K5. Derivatives of 1 substituted at the 2'-position, however, did exhibit cross-resistance to this cell line. The basis for the resistance of this cell line towards CPT is that it possesses a mutant form of topo I. These results suggest that substituents at the 2'-position may be in proximity to the wild-type enzyme. Therefore, we hypothesized that terbenzimidazoles with 2'-substituents could be capable of interacting with the enzyme and thereby influence activity within this class of topo I poisons. 5-Phenylterbenzimidazoles with a hydroxy, hydroxymethyl, mercapto, amino, N-benzoylaminomethyl, chloro, and trifluoromethyl group at the 2'-position were synthesized. In addition, several 2'-ethyl-5-phenylterbenzimidazoles were prepared containing either a methoxy, hydroxy, amino, or N-acetylamino group at the 2-position of the ethyl side-chain. These 2'-substituted 5-phenylterbenzimidazoles were evaluated as topo I poisons and for cytotoxic activity. The presence of a strong electron-withdrawing group at the 2'-position, such as a chloro or trifluoromethyl group, did enhance both topo I poisoning activity and cytotoxicity. Studies on the relative DNA binding affinity of 1 to its 2'-amino and 2'-trifluoromethyl derivatives did exhibit a correlation with their relative differences in biological activity. Copyright (C) 2000 Elsevier Science Ltd.

Heterocyclic topoisomerase poisons

The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.