23747-90-2Relevant articles and documents
Bactericidal urea crown ethers target phosphatidylethanolamine membrane lipids
Herschede, Sarah R.,Gneid, Hassan,Dent, Taylor,Jaeger, Ellen B.,Lawson, Louise B.,Busschaert, Nathalie
, p. 3838 - 3843 (2021)
An increasing number of people are infected with antibiotic-resistant bacteria each year, sometimes with fatal consequences. In this manuscript, we report a novel urea-functionalized crown ether that can bind to the bacterial lipid phosphatidylethanolamine (PE), facilitate PE flip-flop and displays antibacterial activity against the Gram-positive bacterium Bacillus cereus with a minimum inhibitory concentration comparable to that of the known PE-targeting lantibiotic duramycin. This journal is
