23767-32-0

Usage

Uses

Used in Pharmaceutical Industry:
2-(methylsulfonyl)-5-phenyl-1,3,4-oxadiazole is used as a pharmaceutical agent for its anti-inflammatory, antimicrobial, and anticancer properties. It is valued for its potential to modulate various biological pathways and processes, contributing to the development of new therapeutics.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(methylsulfonyl)-5-phenyl-1,3,4-oxadiazole is utilized as an active ingredient in the development of pesticides and other agrochemical products, leveraging its antimicrobial properties to protect crops and enhance agricultural productivity.
Used as a Chemical Intermediate:
2-(methylsulfonyl)-5-phenyl-1,3,4-oxadiazole also serves as an intermediate in the synthesis of various organic molecules, playing a crucial role in the production of a range of chemical compounds with diverse applications across different industries.

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 613-94-5 benzoic acid hydrazide 
• 745743-41-3 1-benzoyl-S-methyl-iso thiosemicarbazide 
• 5351-66-6 benzoyl thiosemicarbazide 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 
• 23288-88-2 2-(methylthio)-5-phenyl-1,3,4-oxadiazole 

Downstream Products

• 130161-33-0 Phenyl-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetonitrile 
• 20228-08-4 2-(2-oxazolin-2-yl)benzhydrazide 
• 96440-18-5 Benzoic acid N'-[1-(5-phenyl-[1,3,4]oxadiazol-2-yl)-4,5-dihydro-1H-imidazol-2-yl]-hydrazide 
• 96440-19-6 Benzoic acid N'-[1-(5-phenyl-[1,3,4]oxadiazol-2-yl)-1,4,5,6-tetrahydro-pyrimidin-2-yl]-hydrazide 
• 130161-38-5 Cyano-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetic acid ethyl ester 
• 20228-07-3 2-(2-thiazolin-2-yl)benzhydrazide 
• 96440-16-3 2-(5,6-dihydro-4H-1,3-oxazin-2-yl)benzhydrazide 
• 130161-36-3 2-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-malononitrile 
• 130161-40-9 2-(5-Phenyl-[1,3,4]oxadiazol-2-yl)-malonic acid diethyl ester 
• 1321878-21-0 2-(dodecylthio)-5-phenyl-1,3,4-oxadiazole 
• 54294-31-4 3-phenyl-5,6-dihydrothiazolo<2,3-c>-s-triazole 
• 96440-17-4 3-phenyl-6,7-dihydro-5H-s-triazolo<3,4-b><1,3>oxazine 
• 473742-96-0 N-acetyl-2,3-butadienyl-(5-phenyl-1,3,4-oxadiazol-2-yl)amine 
• 861229-55-2 2-chloro-benzoic acid N'-(5-phenyl-[1,3,4]oxadiazol-2-yl)-hydrazide 

Relevant academic research and scientific papers

Stable and Rapid Thiol Bioconjugation by Light-Triggered Thiomaleimide Ring Hydrolysis

Maleimide-mediated thiol-specific derivatization of biomolecules is one of the most efficacious bioconjugation approaches currently available. Alarmingly, however, recent work demonstrates that the resulting thiomaleimide conjugates are susceptible to breakdown via thiol exchange reactions. Herein, we report a new class of maleimides, namely o-CH2NHiPr phenyl maleimides, that undergo unprecedentedly rapid ring hydrolysis after thiol conjugation to form stable thiol exchange-resistant conjugates. Furthermore, we overcome the problem of low shelf lives of maleimide reagents owing to their propensity to undergo ring hydrolysis prior to bioconjugation by developing a photocaged version of this scaffold that resists ring hydrolysis. UV irradiation of thiol bioconjugates formed with this photocaged maleimide unleashes rapid thiomaleimide ring hydrolysis to yield the desired stable conjugates within 1 h under gentle, ice-cold conditions.

Chemical modification of lipase for rational enhancement of enantioselectivity

Chemical modifications of the I287C mutant of a Burkholderia cepacia lipase afforded various I287C-X conjugates, among which I287C-PAA bearing an N-phenylacetamide (PAA) moiety showed excellent enantioselectivity and catalytic activity for secondary alcohols. Site-directed chemical modifications are powerful tools to control enantioselective biocatalysis.

COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS

Disclosed are compounds that can be used for treating tuberculosis.

Rapid, stable, chemoselective labeling of thiols with Julia- Kocienski-like reagents: A serum-stable alternative to maleimide-based protein conjugation

Exquisite chemoselectivity for cysteine has been found for methylsulfonylphenyloxadiazole compounds under various buffer conditions. Furthermore, the resulting protein conjugates have superior stability to cysteine-maleimide conjugates in human plasma (HS

Synthesis, antibacterial activities, and 3d-qsar of sulfone derivatives containing 1, 3, 4-oxadiazole moiety

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, respectively. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds.

AMIDE COMPOUNDS

The present invention provides compounds represented by the formula (Ie) and the formula (If) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibitory activity and are useful for the prophylaxis, treatment or improvement of diseases or pathologies caused by high expression or high activation of DGAT

A new route to synthesis of 3,6-diaryl-1,2,4-triazolo[3,4-b]1,3,4- oxadiazoles

Five new 3,6-diaryl-1,2,4-triazolo[3,4-b]1,3,4-oxadiazole derivatives were synthesized by 9 steps from aromatic acids and evaluated for their activities of anticancer and antibacteria. The structures of all new compounds synthesized were elucidated by MS,