23767-79-5

Upstream product

• 1885-22-9 bromomalononitrile 
• 100-52-7 benzaldehyde 
• 1885-23-0 dibromomalononitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 109-77-3 malononitrile 
• 769-42-6 1,3-dimethylbarbituric acid 
• 506-68-3 bromocyane 
• 606-23-5 1H-indene-1,3(2H)-dione 

Downstream Products

• 110108-61-7 2-[(3,5-Diamino-1-phenyl-1H-pyrazol-4-yl)-phenyl-methylene]-malononitrile 
• 110108-66-2 3,6-Diamino-2,4-diphenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile 

Relevant academic research and scientific papers

Pyridinium bromide as a new mediator for electrochemical transformations involving CH-acids

Pyridinium bromide has been tested as a new mediator for electrochemical synthesis of functionalized cyclopropane from alkylidenemalononitriles and CH-acids. The process was performed in an undivided cell with the use of substoichiometric amount of PyHBr

Pyridinium bromide as a mediator in electrochemical reactions: The preparation of cyclopropane-1,1-dicarbonitriles

Pyridinium bromide has been tested as a new mediator for electrochemical transformations in methanol and acetonitrile. An efficient protocol for the synthesis of cyclopropanes via the electrochemical transformations of alkylidenemalononitriles and C-H aci

Synthesis of 3-Arylcyclopropane-1,1,2,2-tetracarbonitriles under Micellar Catalysis

An environmentally benign procedure has been developed for the synthesis of 3-arylcyclopropane- 1,1,2,2-tetracarbonitriles in an aqueous surfactant solution.

Synthesis of Activated Cyclopropanes by MHIRC Strategy: A Facile and Efficient Approach to Spirocyclopropanes Using N-Halosulfon-amides

In this study, a one-pot, three-component reaction of two molecules of indane-1,3-dione with aromatic aldehydes for the synthesis of spirocyclopropylindanediones using poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) (PBBS), N,N,N',N'-tetrabromobenzene-1,3-

Flash preparation of carbenoids: A different performance of cyanogen bromide

Cyanogen halides are known substances for the cyanating reaction. There are a few evidences for bromination reaction too. On the other hand carbenes are known as very important substances due to their remarkable reactions. Unfortunately carbenes at room temperature are very unstable and there is not a simple method for preparation of them. In most cases the isolation is not possible. We have reported a new reliable and fast preparation method of almost stable carbenoids. The mechanism of the formation has been discussed.

Solvent-free, one-pot synthesis of pentasubstituted cyclopropanes in the presence of BrCN and EtONa by milling

A solvent-free, one-pot process for the preparation of pentasubstituted 3-arylcyclopropane-1,1,2,2-tetracarbonitriles in the presence of solid sodium ethoxide by milling was achieved. The one-pot reaction of aromatic aldehydes and dialdehydes with malonon

Electrocatalytic and chemical methods in MHIRC reactions: The first example of the multicomponent assembly of medicinally relevant spirocyclopropylbarbiturates from three different molecules

Electrolysis of aldehydes, barbituric acids, and malononitrile in alcohol in an undivided cell in the presence of sodium bromide results in efficient MHIRC formation of the corresponding spirocyclopropylbarbiturates in 50-65% substance yield. The electroc

A new, fast and easy strategy for one-pot synthesis of full substituted cyclopropanes: Direct transformation of aldehydes to 3-aryl-1,1,2,2- tetracyanocyclopropanes

A new, fast and easy method for one-pot reaction of aromatic aldehydes and dialdehydes with malononitrile and cyanogen bromide has been developed to afford full substituted 3-arylcyclopropane-1,1,2,2-tetracarbonitriles in excellent yields in very short time (about 5 seconds). The structures elucidations were characterized by IR, 1H NMR, 13C NMR, mass spectrometry and X-ray crystallography techniques. For these compounds the crystallographic data showed two structures in mirror image in solid case and one distinct structure in solution. The reaction mechanism was discussed.

One-pot cascade assembling of 3-substituted tetracyanocyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action

The new cascade reaction was found: the formation of cyclopropanes from alkylidenemalononitriles and malononitrile by the only bromine direct action; the action of aqueous bromine on the equal amounts of alkylidenemalononitriles and malononitrile in EtOH-

A new type of cascade reaction: direct conversion of carbonyl compounds and malononitrile into substituted tetracyanocyclopropanes

A new type of chemical cascade reaction was found: the direct formation of cyclopropanes from carbonyl compounds and C-H acid. The action of free halogen or active halogen containing compounds on a mixture of 1 equiv of carbonyl compound and 2 equiv of malononitrile in a basic alcohol solution results in the formation of substituted 1,1,2,2-tetracyanocyclopropanes in 15-80% yield. The latter are well-known precursors for the different bicyclic heterosystems, among them compounds containing a cyclopropane ring and possessing different types of pharmacological activity. Thus, the new, simple and efficient 'one-pot' way to substituted tetracyanocyclopropanes in 50-80% yield was found directly from such simple and reasonable starting compounds as aldehydes, or some cyclic ketones, or substituted cyclohexanones and malononitrile.