237735-95-4

Upstream product

• 60732-17-4 2,5-dimethoxybenzyl bromide 
• 33524-31-1 2,5-dimethoxybenzyl alcohol 
• 184485-46-9 (1S,4aS)-(+)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-1β,4aβ-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)-hexahydro-2,5(3H,6H)-naphthalenedione 
• 184485-47-0 (1S,4aS)-(+)-trans-1α-[(2,5-dimethoxyphenyl)methyl]-1β,4aβ-dimethyl-5-(2-methyl-1,3-dioxolan-2-yl)-2-methyleneoctahydro-5(6H)-naphthalenone 
• 26742-33-6 (4aS)-1,4aβ-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione-5-ethyeneacetal 
• 237735-94-3 C₂₄H₃₆O₄ 
• 274900-31-1 (4aS,5S,8aS)-5-(2,5-Dimethoxy-benzyl)-5,8a-dimethyl-6-methylene-octahydro-naphthalen-1-one 
• 41722-49-0 (S)-1,4a-dimethyl-4,4a,7,8-tetrahydronaphthalene-2,5(3H,6H)-dione 

Downstream Products

• 237735-96-5 (1R,2R,4aS,8aS)-1-(2,5-Dimethoxy-benzyl)-1,2,4a-trimethyl-5-methylene-decahydro-naphthalene 
• 237736-01-5 2-((1R,2R,4aS,8aS)-1,2,4a-Trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-[1,4]benzoquinone 
• 237735-97-6 2-((1R,2R,4aS,8aS)-1,2,4a-Trimethyl-5-methylene-decahydro-naphthalen-1-ylmethyl)-benzene-1,4-diol 

Relevant academic research and scientific papers

Synthetic study of akaterpin: Determination of the relative stereochemistry of the upper decalin moiety with disulfated hydroquinone

In order to establish the stereochemistry of akaterpin, a specific inhibitor of PI-PLC, synthesis of cis-decalin 2 and trans-decalin 3 was carried out. Comparison of NMR spectra of 2 and 3 with that of akaterpin indicated that the upper decalin has a cis-fused structure.

Enantiospecific total synthesis of (+)- and (-)-avarone and -avarol

Enantiopure avarol and its oxidized congener avarone are synthesized in both podal series from an optically pure Wieland-Miescher enone; preliminary results from biochemical studies are summarized.