237756-18-2Relevant academic research and scientific papers
Structure-activity relationship and rational design of 3,4-dephostatin derivatives as protein tyrosine phosphatase inhibitors
Watanabe, Takumi,Suzuki, Takayuki,Umezawa, Yoji,Takeuchi, Tomio,Otsuka, Masami,Umezawa, Kazuo
, p. 741 - 752 (2007/10/03)
Several alkyl- and O-methylated-3,4-dephostatin were synthesized and evaluated for their inhibitory activity toward protein tyrosine phosphatase. Alkyl chains with a length up to that of the pentyl group gave tolerable inhibition, whereas methylation of h
