23780-53-2Relevant academic research and scientific papers
Direct N1-selective alkylation of hydantoins using potassium bases
Shintani, Yumi,Kato, Koichi,Kawami, Masashi,Takano, Mikihisa,Kumamoto, Takuya
, p. 407 - 410 (2021/04/30)
Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the higher acidity of its proton, N3 can be more easily alkylated than N1 under
SOME EXAMPLES OF 5,5-DIPHENYLHYDANTOIN ALKYLATION
Kiec-Kononowicz, Katarzyna,Zejc, Alfred
, p. 761 - 767 (2007/10/02)
The method of N1 and N3 alkylation of 5,5-diphenylhydantoin has been described for some examples.The synthesis of only N1 alkylated compound 11 has been accomplished with ethoxycarbonyl as the N3 protecting grou
