23780-53-2Relevant articles and documents
Direct N1-selective alkylation of hydantoins using potassium bases
Shintani, Yumi,Kato, Koichi,Kawami, Masashi,Takano, Mikihisa,Kumamoto, Takuya
, p. 407 - 410 (2021/04/30)
Hydantoins, including the antiepileptic drug phenytoin, contain an amide nitrogen and an imide nitrogen, both of which can be alkylated. However, due to the higher acidity of its proton, N3 can be more easily alkylated than N1 under