2380-77-0

Basic information

• Product Name: 3-(3-amino-1-hydroxypropyl)phenol
• Synonyms: 3-(3-amino-1-hydroxypropyl)phenol
• CAS NO: 2380-77-0
• Molecular Weight: 167.208
• Mol File: 2380-77-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(3-amino-1-hydroxypropyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-amino-1-hydroxypropyl)phenol(2380-77-0)
• EPA Substance Registry System: 3-(3-amino-1-hydroxypropyl)phenol(2380-77-0)

Safety Data

• Hazardous Substances Data: 2380-77-0(Hazardous Substances Data)

Upstream product

• 1141782-08-2 3-hydroxy-3-(3-hydroxyphenyl)propanenitrile 
• 591-20-8 3-Bromophenol 

Downstream Products

• 1141782-09-3 tert-butyl 3-hydroxy-3-(3-hydroxyphenyl)propylcarbamate 

Relevant articles and documents

Rapid Access to γ-Amino-α-aryl Alcohol Scaffolds via an Enamine-Based Heck Coupling

The γ-amino-α-aryl alcohol is a key functional group for the design of inhibitors directed toward a critical family of metabolic enzymes. Here we report the transformation of simple aryl halides to a highly functionalized benzyl (3-oxo-3-arylpropyl)carbamate intermediate that can rapidly be converted to a high value γ-amino-α-aryl alcohol. This chemistry is realized through a two-step process involving an enamine-based Heck coupling (EBHC) followed by a one-pot catalytic Cbz-deprotection and ketone reduction of EBHC products.

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