1141782-08-2Relevant academic research and scientific papers
Rational tuning of visual cycle modulator pharmacodynamics
Kiser, Philip D.,Zhang, Jianye,Palczewski, Krzysztof,Badiee, Mohsen,Tochtrop, Gregory P.,Peachey, Neal S.,Kinoshita, Junzo
, p. 131 - 145 (2017)
Modulators of the visual cycle have been developed for treatment of various retinal disorders. These agents were designed to inhibit retinoid isomerase [retinal pigment epithelium-specific 65 kDa protein (RPE65)], the rate-limiting enzyme of the visual cy
VISUAL CYCLE MODULATORS
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Paragraph 00154, (2018/09/19)
A method of treating an ocular disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of a retinal sequestering compound of formula (I).
PRODUCTION METHOD FOR OPTICALLY ACTIVE ALCOHOL COMPOUND
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Paragraph 0331, (2016/06/06)
A method for stereoselectively producing an optically active alcohol compound. The optically active alcohol compound of Formula (8) can be produced in high yield and high selectivity from the compound of Formula (3), and the production method that is useful industrially and the intermediates therefor can be provided. In formulae, R1 is a hydrogen atom, C1-6 alkyl, C1-6 alkyl optionally substituted with R3, or the like, R2 is cyano or —CH2N(R5)R4, and R3 is C3-8 cycloalkyl.
COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
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Page/Page column 240-241, (2010/05/13)
Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
