23806-17-9Relevant academic research and scientific papers
Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis of Multisubstituted Thiophenes
Kurandina, Daria,Gevorgyan, Vladimir
, p. 1804 - 1807 (2016)
The rhodium-catalyzed transannulation reaction between 1,2,3-thiadiazoles and alkynes, proceeding via intermediacy of the previously unknown Rh thiavinyl carbene, toward a highly efficient and regioselective synthesis of up to fully substituted thiophenes is described.
Utilizing an Encapsulated Solution of Reagents to Achieve the Four-Component Synthesis of (Benzo)Thiophene Derivatives
Shen, Chaoren,Spannenberg, Anke,Auer, Matthias,Wu, Xiao-Feng
supporting information, p. 941 - 946 (2017/03/27)
Reagent capsules can help to resolve the compatibility problem of reagents in multicomponent processes. Herein we demonstrate a facile method for encapsulating smelly liquid chemicals and its application in a modular palladium-catalyzed carbonylative synthesis of multi-substituted thiophenes from terminal alkynes and aryl iodides as well as a palladium-catalyzed carbonylative synthesis of benzothiophene derivatives from aryl iodides and arylboronic acids. Here, the capsule plays a pivotal role in solving the issues on reaction condition incompatibilities and selectivity of multicomponent reactions as well as avoiding deactivation of the catalyst by releasing the reagents when the reaction temperature is raised. It greatly facilitates the development of highly-efficient multicomponent reactions and demonstrates a modular pathway to obtain functionalized molecules. (Figure presented.).
