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2-[2-(4-CHLOROPHENYL)-4-PHENYL-1,3-THIAZOL-5-YL]ACETIC ACID is a complex chemical compound that features a thiazole ring fused with a phenyl group and a chlorophenyl group, all attached to an acetic acid moiety. This thiazole derivative is recognized for its potential anti-inflammatory and analgesic properties, positioning it as a promising candidate for pharmaceutical development. Its molecular structure indicates a possible role as an inhibitor of cyclooxygenase enzymes, which are pivotal in the body's inflammatory and pain response pathways. Ongoing research is exploring the compound's properties and its potential applications in medicine.

23821-72-9

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23821-72-9 Usage

Uses

Used in Pharmaceutical Industry:
2-[2-(4-CHLOROPHENYL)-4-PHENYL-1,3-THIAZOL-5-YL]ACETIC ACID is used as a potential therapeutic agent for its anti-inflammatory and analgesic activities. 2-[2-(4-CHLOROPHENYL)-4-PHENYL-1,3-THIAZOL-5-YL]ACETIC ACID is being investigated for its ability to inhibit cyclooxygenase enzymes, which are integral to the inflammatory and pain pathways, offering a new avenue for the treatment of conditions characterized by inflammation and pain.
Used in Drug Development Research:
In the field of drug development, 2-[2-(4-CHLOROPHENYL)-4-PHENYL-1,3-THIAZOL-5-YL]ACETIC ACID serves as a subject of ongoing research to understand its full potential and mechanism of action. This research is crucial for the advancement of pharmaceuticals targeting inflammatory diseases and pain management, potentially leading to the development of new drugs with improved efficacy and reduced side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 23821-72-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,8,2 and 1 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23821-72:
(7*2)+(6*3)+(5*8)+(4*2)+(3*1)+(2*7)+(1*2)=99
99 % 10 = 9
So 23821-72-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H12ClNO2S/c18-13-8-6-12(7-9-13)17-19-16(11-4-2-1-3-5-11)14(22-17)10-15(20)21/h1-9H,10H2,(H,20,21)

23821-72-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-(4-Chlorophenyl)-4-phenyl-1,3-thiazol-5-yl]-acetic acid

1.2 Other means of identification

Product number -
Other names 2-[2-(4-CHLOROPHENYL)-4-PHENYL-1,3-THIAZOL-5-YL]ACETIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23821-72-9 SDS

23821-72-9Downstream Products

23821-72-9Relevant academic research and scientific papers

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Rist, ystein,Grimstrup, Marie,Receveur, Jean-Marie,Frimurer, Thomas M.,Ulven, Trond,Kostenis, Evi,Hoegberg, Thomas

scheme or table, p. 1177 - 1180 (2010/06/15)

Structure-activity relationships of three related series of 4-phenylthiazol-5-ylacetic acids, derived from two hits emanating from a focused library obtained by in silico screening, have been explored as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. Several compounds with double digit nanomolar binding affinity and full antagonistic efficacy for human CRTH2 receptor were obtained in all subclasses. The most potent compound was [2-(4-chloro-benzyl)-4-(4-phenoxy-phenyl)-thiazol-5-yl]acetic acid having an binding affinity of 3.7 nM and functional antagonistic effect of 66 nM in a BRET and 12 nM in a cAMP assay with no functional activity for the other PGD2 DP receptor (27 μM in cAMP).

Therapeutic and diagnostic ligand systems comprising transport molecule binding properties and medicaments containing the same

-

, (2008/06/13)

The invention relates to transport molecule binding ligand compounds which comprise a therapeutically and/or diagnostically active substance and a carrier molecule-affine substance with a high association constant to the carrier molecule. The invention also relates to medicaments containing these ligand compounds and to diagnostic kits.

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