53515-22-3

Usage

Uses

Used in Pharmaceutical Research:
3-Bromo-4-oxo-4-phenylbutanoic acid is used as a key building block in pharmaceutical research for its potential role in the development of new drugs and pharmaceuticals. Its unique structure and properties contribute to its value in the synthesis of various medicinal compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Bromo-4-oxo-4-phenylbutanoic acid is employed as a compound with demonstrated biological and pharmacological activities. Its presence in the synthesis of drugs can lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Organic Synthesis:
3-Bromo-4-oxo-4-phenylbutanoic acid is utilized as a versatile intermediate in organic synthesis, where its reactivity and structural features enable the creation of a wide range of chemical products, including complex organic molecules and specialty chemicals.
Used in Drug Discovery:
3-BROMO-4-OXO-4-PHENYLBUTANOIC ACID is also used in drug discovery processes, where its unique properties can be leveraged to identify and optimize lead compounds with potential therapeutic applications. Its presence in the development pipeline can accelerate the discovery of new pharmaceuticals with innovative mechanisms of action.

InChI:InChI=1/C10H9BrO3/c11-8(6-9(12)13)10(14)7-4-2-1-3-5-7/h1-5,8H,6H2,(H,12,13)/p-1/t8-/m1/s1

Upstream product

• 2051-95-8 succinylbenzene 
• 67-66-3 chloroform 
• 7726-95-6 bromine 

Downstream Products

• 716371-78-7 (2-methylsulfanyl-4-phenyl-thiazol-5-yl)-acetic acid 
• 859482-70-5 (4-phenyl-thiazol-5-yl)-acetic acid 
• 34272-66-7 (2-methyl-4-phenyl-thiazol-5-yl)-acetic acid 
• 583-06-2 3-benzoylacrylic acid 
• 23821-80-9 (4-phenyl-2-p-tolyl-thiazol-5-yl)-acetic acid 
• 23821-64-9 [2-(4-methoxy-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid ethyl ester 
• 23821-77-4 (4-phenyl-2-m-tolyl-thiazol-5-yl)-acetic acid 
• 53514-91-3 [2-(2,6-dichloro-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 53514-88-8 [2-(4-bromo-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 53514-89-9 [2-(4-isopropyl-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 23821-84-3 (2-naphthalen-2-yl-4-phenyl-thiazol-5-yl)-acetic acid 
• 23821-79-6 2-(2-chlorophenyl)-4-phenylthiazole-5-acetic acid 
• 23821-72-9 [2-(4-chloro-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 
• 18046-20-3 [2-(4-dimethylamino-phenyl)-4-phenyl-thiazol-5-yl]-acetic acid 

Relevant academic research and scientific papers

Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 1

Structure-activity relationships of three related series of 4-phenylthiazol-5-ylacetic acids, derived from two hits emanating from a focused library obtained by in silico screening, have been explored as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) antagonists. Several compounds with double digit nanomolar binding affinity and full antagonistic efficacy for human CRTH2 receptor were obtained in all subclasses. The most potent compound was [2-(4-chloro-benzyl)-4-(4-phenoxy-phenyl)-thiazol-5-yl]acetic acid having an binding affinity of 3.7 nM and functional antagonistic effect of 66 nM in a BRET and 12 nM in a cAMP assay with no functional activity for the other PGD2 DP receptor (27 μM in cAMP).

AN ALTERNATIVE ROUTE TO 4-BENZOYL-2-AZETIDINONES

Cyclodehydrohalogenation by terminal N1-C4 bond formation affords N-aryl-4-benzoyl-2-azetidinones from 3-benzoyl-3-bromopropionanilides in an unequivocal annelation process.