23826-56-4

Usage

Explanation

This is the full chemical name of the compound, which describes its structure and components.

Explanation

The molecular formula represents the number of carbon (C), hydrogen (H), nitrogen (N), and oxygen (O) atoms in the compound, which is C13H11NO2.

Explanation

Acetylpyridine is a widely used name for the compound, which is derived from its structure, consisting of a pyridine ring and an acetyl group.

Explanation

The compound appears as a yellow solid with a crystalline structure, which is typical for many organic compounds.

Explanation

Acetylpyridine has a pleasant, sweet, and floral odor, which makes it suitable for use as a flavoring agent.

Explanation

Due to its pleasant odor, acetylpyridine is used as a flavoring agent in the food industry to enhance the taste and aroma of various products.

Explanation

The sweet, floral scent of acetylpyridine also makes it a valuable component in the production of perfumes.

Explanation

Acetylpyridine serves as a solvent in the pharmaceutical industry, helping to dissolve and stabilize active ingredients in medications.

Explanation

Research has shown that acetylpyridine may have potential antioxidant and anti-inflammatory properties, which could be beneficial for human health.

Explanation

Acetylpyridine may pose a risk to human health if not handled and used properly. It is essential to follow safety precautions and guidelines when working with 1-PHENYL-2-(PYRIDIN-3-YL)ETHANE-1,2-DIONE to minimize potential hazards.

Physical Appearance

Yellow Crystalline Solid

Odor

Sweet, Floral

Usage in Food Industry

Flavoring Agent

Usage in Perfume Production

Component in Perfumes

Usage in Pharmaceutical Industry

Solvent

Potential Health Benefits

Antioxidant and Anti-inflammatory Properties

Safety Precautions

Risk to Human Health if Mishandled

Upstream product

• 13238-38-5 3-(2-phenylethynyl)pyridine 
• 6443-85-2 3-pyridinylacetonitrile 
• 1081-48-7 1-phenyl-2-(pyridin-3-yl)ethanone 
• 626-55-1 3-Bromopyridine 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Gold-Catalyzed Oxidation of Internal Alkynes into Benzils and its Application for One-Pot Synthesis of Five-, Six-, and Seven-Membered Azaheterocycles

Internal alkynes have been shown to undergo oxidation to substituted benzils (1,2-diarylethane-1,2-diones) by α-picoline N-oxide in the presence of Ph3PAuNТf2 (5 mol-%). In addition to the unsubstituted benzil, the method allows preparing, under markedly mild conditions (50 °C in chlorobenzene), various non-symmetrical products, including heteroaromatic versions thereof which are much more difficult to obtain otherwise. This gold(I)-catalyzed transformation was integrated into one-pot reaction sequence delivering a range of 5- to 7-membered ring systems (imidazoles, quinoxalines, 1,2,4-triazines, pyrazines, and 1,4-diazepines), thus linking these important heterocyclic motifs to the internal alkyne reagent space.

Electrochemical synthesis of 1,2-diketones from alkynes under transition-metal-catalyst-free conditions

We report an electrochemical protocol for the direct oxidation of internal alkynes in air to provide 1,2-diketones. A variety of functional groups and heterocycle-containing substrates can be tolerated well under mild conditions.

B2pin2-mediated copper-catalyzed oxidation of alkynes into 1,2-diketones using molecular oxygen

An intriguing aerobic oxidation of alkynes through copper catalysis is described, in which bis(pinacolato)diboron (B2pin2) played a dominant intermediary role in the formation 1,2-diketones. This novel protocol, which can be performed at room temperature, is versatile for various substituted alkynes, including diarylalkynes and arylalkylalkynes. The mechanism of this reaction was preliminarily investigated by control experiments.

Metal-Free Iodine-Catalyzed Oxidation of Ynamides and Diaryl Acetylenes into 1,2-Diketo Compounds

Metal-free oxidation of ynamides is described, employing pyridine-N-oxides as oxidants under molecular iodine catalysis. In stark contrast to Br?nsted acid catalysis, iodophilic activation of ynamides diverts the reaction manifold into a dioxygenation pathway. This oxidation is very rapid at room temperature with only 2.5 mol % I2. Furthermore, this protocol could be extended to nonactivated alkynes, such as diarylacetylenes, to deliver various benzil derivatives.

Two-Step One-Pot Synthesis of Unsymmetrical (Hetero)Aryl 1,2-Diketones by Addition-Oxygenation of Potassium Aryltrifluoroborates to (Hetero)Arylacetonitriles

An efficient one-pot two-step procedure for the synthesis of unsymmetrical (hetero)aryl 1,2-diketones has been developed. The reaction proceeds through a palladium-catalyzed nucleophilic addition of potassium aryltrifluoroborates to aliphatic nitriles followed by a copper-catalyzed aerobic benzylic C–H oxygenation using molecular oxygen as a green oxidant. This represents the first example of the direct synthesis of unsymmetrical diaryl 1,2-diketones from arylacetonitriles. This method utilizes inexpensive, stable, nontoxic, and readily available starting materials, is highly effective in the presence of both electron-rich and electron-poor nitriles and aryltrifluoroborates, and tolerates a wide variety of functional groups. The synthetic utility of this transformation was shown by increasing the scale of the reaction and by carrying out the one-pot protocol for the preparation of quinoxaline and benzimidazole derivatives. A plausible reaction mechanism has also been proposed.

Copper-catalyzed synthesis of 1,2-diketones via oxidation of alkynes

The direct oxidation of internal alkynes proceeds efficiently in the presence of CuI as a catalyst to afford the corresponding 1,2-diketones in good yields. This strategy offers a simple and efficient route for the synthesis of 1,2-diketones from an inexpensive copper catalyst and easily available internal alkynes. The advantage of present protocol is further demonstrated by the synthesis of quinoxaline derivatives from alkynes and 1,2-diaminobenzene via one-pot procedure.

Efficient synthetic route to bisaryl ketones via copper-catalyzed C-C triple bonds cleavage

An efficient copper-catalyzed aerobic synthesis of bisaryl ketones from 1,2-diarylalkynes via C-C triple bonds cleavage has been demonstrated. The aniline compounds were found to be crucial in our conditions and a plausible mechanism was put forward. This reaction constitutes a new transformation from 1,2-diarylalkynes into bisaryl ketones with a practical, neutral, and mild synthetic approach.

Pd/Cu-catalyzed oxidation of alkynes into 1,2-diketones using DMSO as the oxidant

A facile and practical method for the palladium/copper-catalyzed transformation of internal alkynes into 1,2-diketones has been described, affording the desired products in moderate to excellent yields. The mechanistic studies were also preliminarily pursued using diphenyl sulfoxide as the oxidant, and the diphenyl sulfide was isolated as the reduced product.

Facile aerobic photo-oxidative synthesis of α-diketones from alkynes

We report a useful method for facile aerobic photo-oxidative synthesis of α-diketones from alkynes with MgBr2·OEt2. This procedure provides a practical synthetic method of α-diketones using easily handled bromine sources, harmless visible light, and molecular oxygen as terminal oxidant.

Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation

The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles