23836-43-3

Usage

Uses

Used in Pharmaceutical Formulations:
Cholesterol Ethyl Carbonate is used as a solubility enhancer for cholesterol in pharmaceutical formulations, addressing the challenge of cholesterol's poor water solubility and thereby improving its bioavailability for therapeutic applications.
Used in Cardiovascular Health:
Cholesterol Ethyl Carbonate is used as a cholesterol-lowering agent, potentially reducing the risk of cardiovascular disease by managing cholesterol levels in the body.
Used in Drug Delivery Systems Development:
Cholesterol Ethyl Carbonate is being investigated for its use in the development of innovative drug delivery systems, which may enhance the efficacy and targeted delivery of therapeutic agents.
Used in Research and Development:
Cholesterol Ethyl Carbonate serves as a valuable tool in research for studying the effects of cholesterol in the body, aiding in the understanding of its role in various physiological and pathological processes.

InChI:InChI=1/C30H50O3/c1-7-32-28(31)33-23-15-17-29(5)22(19-23)11-12-24-26-14-13-25(21(4)10-8-9-20(2)3)30(26,6)18-16-27(24)29/h11,20-21,23-27H,7-10,12-19H2,1-6H3/t21-,23+,24+,25-,26+,27+,29+,30-/m1/s1

Upstream product

• 7144-08-3 Cholesteryl chloroformate 
• 57-88-5 cholesterol 
• 541-41-3 chloroformic acid ethyl ester 
• 57-88-5 cholesterol 
• 105-58-8 Diethyl carbonate 
• 570-85-4 5α-cholestane-3β,6β-diol 
• 73532-41-9 3β,6β-bis(pyrrolidin-1-ylthiocarbonyloxy)-5α-cholestane 
• 73532-39-5 3β,6β-bis<(methylthio)thiocarbonyloxy>-5α-cholestane 
• 64-17-5 ethanol 

Downstream Products

• 747-90-0 3,5-cholestadiene 
• 17110-51-9 cholesteric-oleyl-carbonate 

Relevant academic research and scientific papers

An efficient synthesis of organic carbonates using nanocrystalline magnesium oxide

An efficient and selective synthesis of organic carbonates using nanocrystalline magnesium oxide has been realized by the direct condensation of alcohols and diethyl carbonate. The catalyst is quantitatively recovered by simple centrifugation and can be reused for four cycles with almost consistent activity.

Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya

Sitostanol has been converted in high to near-quantitative extent to the corresponding long-chain acyl esters via esterification with oleic acid or transesterification with methyl oleate or trioleoylglycerol using immobilized lipases from Rhizomucor miehei (Lipozyme IM) and Candida antarctica (lipase B, Novozym 435) as biocatalysts in vacuo (20-40 mbar) at 80 °C, whereas the conversion was markedly lower at 60 and 40 °C. Corresponding conversions observed with papaya (Carica papaya) latex lipase were generally lower. High conversion rates observed in transesterification of sitostanol with methyl oleate at 80 °C using Lipozyme IM were retained even after 10 repeated uses of the biocatalyst. Saturated sterols such as sitostanol and 5α-cholestan-3β-ol were the preferred substrates as compared to Δ5-unsaturated cholesterol in transesterification reactions with methyl oleate using Lipozyme IM. Transesterification of cholesterol with diethyl 1,8-octanedioate using Lipozyme IM in vacuo yielded methylcholesteryl 1,8-octanedioate (75%) and dicholesteryl 1,8-octanedioate (5%). However, transesterification of cholesterol with diethyl carbonate and that of oleyl alcohol with ethylcholesteryl carbonate, both catalyzed by Lipozyme IM, gave ethylcholesteryl carbonate and oleylcholesteryl carbonate, respectively, in low yield (20%). Moreover, cholesterol was transesterified with ethyl dihydrocinnamate using Lipozyme IM to give cholesteryl dihydrocinnamate in moderate yield (56%), whereas the corresponding reaction of lanosterol gave lanosteryl oleate in low yield (14%).

Asymmetric hydrogenation of amino acid precursors promoted by a new type of cholesterol amphiphiles: Investigation of aggregation behaviour and stereoselective effects

Reaction of 2-hydroxyethanesulfonic acid sodium salt, 3-hydroxypropanesulfonic acid sodium salt or 2-aminoethanesulfonic acid sodium salt with cholest-5-en-3β-ol-3-chloroformate yields the chiral amphiphilic compounds 2-(cholest-5-en-3β)oxy-carbonyloxy-et

The Deoxygenation of NN-Dialkylaminothiocarbonyloxyalkanes

The title compounds were converted into alkanes in high yield on reduction with potassium and 18-crown-6 in t-butylamine.Thereby both primary and secondary alcohols were conveniently deoxygenated.