238401-92-8

Upstream product

• 238401-88-2 (R)-2,3-diO-dibenzylglyceraldehyde (S)-α-methylbenzylimine 
• 238401-89-3 (R)-N-[(S)-α-methylbenzyl]-2-[(S)-1,2-dibenzyloxyethyl]-5,6-dihydro-4-pyridone 

Downstream Products

• 238401-93-9 (R)-N-[(S)-α-methylbenzyl]-2-[(S)-1,2-dibenzyloxyethyl]-4-(1,3-dioxolan-2-yl)piperidine 
• 927385-95-3 (E)-(R)-4-tert-butoxycarbonylmethylene-2-[(S)-1,2-dibenzyloxyethyl]-1-[(S)-1-phenylethyl]piperidine 
• 1072030-81-9 (R)-2-[(S)-1,2-dibenzyloxyethyl]-4-piperidone 
• 1072030-75-1 (E/Z)-(R)-4-cyanomethylene-2-[(S)-1,2-bis(benzyloxy)ethyl]-1-[(S)-1-phenylethyl]piperidine 

Relevant academic research and scientific papers

Base-controlled diastereodivergent synthesis of (R)- and (S)-2-substituted-4-alkylidenepiperidines by the Wadsworth-Emmons reaction

(Chemical Equation Presented) Significant base and reaction time effects have been observed in the Wadsworth-Emmons reaction between a chiral 2-substituted-4-oxopiperidine and phosphonates. In the reactions carried out using a large excess of DBU as the b

Unexpected epimerization at C2 in the Horner-Wadsworth-Emmons reaction of chiral 2-substituted-4-oxopiperidines

The observed epimerization at C2 in the Horner-Wadsworth-Emmons (HWE) reaction of chiral 2-substituted-4-oxopiperidines has been investigated and, on the basis of the experimental results, a mechanism for this unexpected process has been propos

Study of the reaction of imines derived from (R)-glyceraldehyde with Danishefsky's diene

N-Benzylimines derived from conveniently protected (R)-glyceraldehyde underwent diastereoselective tandem Mannich-Michael reaction with Danishefsky's diene in the presence of Lewis acids. The temperature, catalyst and solvent dependence of the product rat