238420-46-7Relevant academic research and scientific papers
A facile synthesis of 6-substituted benzimidazo[1,2-c]quinazolines under microwave irradiation
Khajavi, Mohammad S.,Rad-Moghadam, Kurosh,Hazarkhani, Hasan
, p. 2617 - 2624 (1999)
Microwave irradiation promoted the high-yield cyclocondensation of ortho esters (1a-f) with 2-(2-aminophenyl)benzimidazole (2), as the catalyst was no longer needed.
Benzimidazoquinazolines as new potent anti-TB chemotypes: Design, synthesis, and biological evaluation
Chakraborti, Asit K.,Dhameliya, Tejas M.,Jadhavar, Pradeep S.,Krishna, Vagolu Siva,Patel, Kshitij I.,Saha, Nirjhar,Sriram, Dharmarajan,Vaja, Maulikkumar D.
, (2020/03/31)
In search for new molecular entities as anti-TB agents, the benzimidazoquinazoline polyheterocyclic scaffold has been designed adopting the scaffold hopping strategy. Thirty-two compounds have been synthesized through an improved tandem decarboxylative nucleophilic addition cyclocondensation reaction of o-phenylenediamine with isatoic anhydride followed by further cyclocondensation of the intermediately formed 2-(o-aminoaryl)benzimidazole with trialkyl orthoformate/acetate. The resultant benzimidazoquinazolines were evaluated in vitro for anti-TB activity against M. tuberculosis H37Rv (ATCC27294 strain). Fourteen compounds exhibiting MIC values in the range of 0.4–6.25 μg/mL were subjected to cell viability test against RAW 264.7 cell lines and were found to be non-toxic (30% inhibition at 50 μg/mL). The active compounds were further evaluated against INH resistant Mtb strains. The most active compound 6x [MIC (H37Rv) of 0.4 μg/mL] and the compound 6d [MIC (H37Rv) of 0.78 μg/mL] were also found to be active against INH resistant Mtb strain with MIC values of 12.5 and 0.78 μg/mL, respectively.
Microwave assisted synthesis of fused benzimidazoles
Davoodnia
experimental part, p. 1591 - 1594 (2012/04/10)
Microwave assisted synthesis of some benzimidazo[1,2-c]-quinazolines and benzimidazo[1,2-c][1,2,4]triazolo[4,3-a]quinazolines from the reaction of suitable functionalized benzimidazole and benzimidazoquinazolines with triethylorthoesters in solvent-free conditions is described. In comparison with classical conditions the reactions are faster and the yields are higher under microwave irradiation.
